Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formation

SARS-CoV-2 infection causes spike-dependent fusion of infected cells with ACE2 positive neighboring cells, generating multi-nuclear syncytia that are often associated with severe COVID. To better elucidate the mechanism of spike-induced syncytium formation, we combine chemical genetics with 4D confo...

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Detalles Bibliográficos
Autores principales: Zhang, Qi, Tang, Weichun, Stancanelli, Eduardo, Jung, Eunkyung, Syed, Zulfeqhar, Pagadala, Vijayakanth, Saidi, Layla, Chen, Catherine Z., Gao, Peng, Xu, Miao, Pavlinov, Ivan, Li, Bing, Huang, Wenwei, Chen, Liqiang, Liu, Jian, Xie, Hang, Zheng, Wei, Ye, Yihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507024/
https://www.ncbi.nlm.nih.gov/pubmed/37723160
http://dx.doi.org/10.1038/s41467-023-41453-w

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