Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors

The pro-inflammatory state of macrophages, underpinned by their metabolic condition, is essentially affecting their capacity of combating tumor cells. Here we find, via a pooled metabolic gene knockout CRISPR screen that KEAP1 and ACOD1 are strong regulators of the pro-inflammatory state in macropha...

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Detalles Bibliográficos
Autores principales: Wang, Xudong, Su, Siyu, Zhu, Yuqing, Cheng, Xiaolong, Cheng, Chen, Chen, Leilei, Lei, Anhua, Zhang, Li, Xu, Yuyan, Ye, Dan, Zhang, Yi, Li, Wei, Zhang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507032/
https://www.ncbi.nlm.nih.gov/pubmed/37723178
http://dx.doi.org/10.1038/s41467-023-41470-9

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