Bisphosphonate conjugation enhances the bone-specificity of NELL-1-based systemic therapy for spaceflight-induced bone loss in mice

Microgravity-induced bone loss results in a 1% bone mineral density loss monthly and can be a mission critical factor in long-duration spaceflight. Biomolecular therapies with dual osteogenic and anti-resorptive functions are promising for treating extreme osteoporosis. We previously confirmed that...

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Detalles Bibliográficos
Autores principales: Ha, Pin, Kwak, Jin Hee, Zhang, Yulong, Shi, Jiayu, Tran, Luan, Liu, Timothy Pan, Pan, Hsin-Chuan, Lee, Samantha, Kim, Jong Kil, Chen, Eric, Shirazi-Fard, Yasaman, Stodieck, Louis S., Lin, Andy, Zheng, Zhong, Dong, Stella Nuo, Zhang, Xinli, Wu, Benjamin M., Ting, Kang, Soo, Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507033/
https://www.ncbi.nlm.nih.gov/pubmed/37723136
http://dx.doi.org/10.1038/s41526-023-00319-7

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