Cargando…
Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils
Neutrophils are the most abundant leukocyte in humans and provide a critical early line of defense as part of our innate immune system. We perform a comprehensive, genome-wide assessment of the molecular factors critical to proliferation, differentiation, and cell migration in a neutrophil-like cell...
Autores principales: | Belliveau, Nathan M., Footer, Matthew J., Akdoǧan, Emel, van Loon, Aaron P., Collins, Sean R., Theriot, Julie A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507112/ https://www.ncbi.nlm.nih.gov/pubmed/37723145 http://dx.doi.org/10.1038/s41467-023-41452-x |
Ejemplares similares
-
Neutrophil‐like HL‐60 cells expressing only GFP‐tagged β‐actin exhibit nearly normal motility
por: Garner, Rikki M., et al.
Publicado: (2020) -
Leading edge competition promotes context-dependent responses to receptor inputs to resolve directional dilemmas in neutrophil migration
por: Hadjitheodorou, Amalia, et al.
Publicado: (2023) -
Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity
por: Hadjitheodorou, Amalia, et al.
Publicado: (2021) -
Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing
por: Bell, George R. R., et al.
Publicado: (2021) -
Context-Dependent Role of Vinculin in Neutrophil Adhesion, Motility and Trafficking
por: Wilson, Zachary S., et al.
Publicado: (2020)