Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation

Nonalcoholic steatohepatitis (NASH) represents an inflammatory subtype of nonalcoholic fatty liver disease (NAFLD). The activation of the NOD-like receptor protein 3 (NLRP3) inflammasome triggers pyroptosis, thus propelling the progression from simple steatosis to NASH. Silibinin, a hepatoprotective...

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Detalles Bibliográficos
Autores principales: Mai, Meiqing, Wang, Ya, Luo, Mengliu, Li, Zhongxia, Wang, Di, Ruan, Yongdui, Guo, Honghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507139/
https://www.ncbi.nlm.nih.gov/pubmed/37731666
http://dx.doi.org/10.1016/j.bbrep.2023.101545

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