Smoking induces WEE1 expression to promote docetaxel resistance in esophageal adenocarcinoma

Esophageal adenocarcinoma (EAC) patients have poor clinical outcomes, with an overall 5-year survival rate of 20%. Smoking is a significant risk factor for EAC. The role of WEE1, a nuclear kinase that negatively regulates the cell cycle in normal conditions, in EAC tumorigenesis and drug resistance...

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Detalles Bibliográficos
Autores principales: Islam, Md Obaidul, Thangaretnam, Krishnapriya, Lu, Heng, Peng, Dunfa, Soutto, Mohammed, El-Rifai, Wael, Giordano, Silvia, Ban, Yuguang, Chen, Xi, Bilbao, Daniel, Villarino, Alejandro V., Schürer, Stephan, Hosein, Peter J., Chen, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507159/
https://www.ncbi.nlm.nih.gov/pubmed/37732296
http://dx.doi.org/10.1016/j.omto.2023.08.012

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