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Engineering a CEACAM1 Variant with the Increased Binding Affinity to TIM-3 Receptor
BACKGROUND: TIM-3 is an inhibitory receptor expressed in a variety of cells, including dendritic cells, T-helper 1 lymphocytes, and natural killer cells. Binding of this protein to its ligand, CEACAM1, causes T-cell exhaustion, a specific condition in which effector T cells lose their ability to pro...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Pasteur Institute of Iran
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507288/ https://www.ncbi.nlm.nih.gov/pubmed/37525418 http://dx.doi.org/10.52547/ibj.3874 |