Cargando…

Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice

INTRODUCTION: In this study, we report a novel therapeutic approach using B lymphocytes to attract islet-specific T cells in the non-obese diabetic (NOD) mouse model and prevent the development of autoimmune diabetes. Rather than using the antibody receptor of B cells, this approach utilizes their p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Dawei, Kakabadse, Dimitri, Fishman, Sigal, Weinstein-Marom, Hadas, Davies, Joanne, Boldison, Joanne, Thayer, Terri C., Wen, Li, Gross, Gideon, Wong, F. Susan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507356/ https://www.ncbi.nlm.nih.gov/pubmed/37731505 http://dx.doi.org/10.3389/fimmu.2023.1227133

Ejemplares similares

B cell depletion reduces T cell activation in pancreatic islets in a murine autoimmune diabetes model
por: Da Rosa, Larissa C., et al.
Publicado: (2018)

Genetic Modification of Tumor-Infiltrating Lymphocytes via Retroviral Transduction
por: Weinstein-Marom, Hadas, et al.
Publicado: (2021)

Regulatory B Cells: Role in Type 1 Diabetes
por: Boldison, Joanne, et al.
Publicado: (2021)

Phenotypically distinct anti-insulin B cells repopulate pancreatic islets after anti-CD20 treatment in NOD mice
por: Boldison, Joanne, et al.
Publicado: (2019)

Implementing Logic Gates for Safer Immunotherapy of Cancer
por: Savanur, Mohammed Azharuddin, et al.
Publicado: (2021)

Characterizing T Cells in SCID Patients Presenting with Reactive or Residual T Lymphocytes
por: Lev, Atar, et al.
Publicado: (2012)

Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes
por: Boldison, Joanne, et al.
Publicado: (2022)

Islet-Like Structures Generated In Vitro from Adult Human Liver Stem Cells Revert Hyperglycemia in Diabetic SCID Mice
por: Navarro-Tableros, Victor, et al.
Publicado: (2018)

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8(+) T Cells
por: Pearson, James A., et al.
Publicado: (2016)

A reproducible method for the expansion of mouse CD8 + T lymphocytes
por: Lewis, Mark D., et al.
Publicado: (2015)

Type 1 diabetes and engineering enhanced islet transplantation
por: Jeyagaran, Abiramy, et al.
Publicado: (2022)

Evidence of functional lymphocytes in some (leaky) scid mice
Publicado: (1988)

Intraperitoneal administration of human “Neo-Islets”, 3-D organoids of mesenchymal stromal and pancreatic islet cells, normalizes blood glucose levels in streptozotocin-diabetic NOD/SCID mice: Significance for clinical trials
por: Westenfelder, Christof, et al.
Publicado: (2021)

Engineering Islets From Stem Cells: The Optimal Solution for the Treatment of Diabetes?
por: Du, Suya, et al.
Publicado: (2022)

Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies
por: Bram, Yaron, et al.
Publicado: (2014)

Bio-Engineering of Pre-Vascularized Islet Organoids for the Treatment of Type 1 Diabetes
por: Wassmer, Charles-Henri, et al.
Publicado: (2022)

Genetics of SCID
por: Cossu, Fausto
Publicado: (2010)

Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes
por: Boldison, Joanne, et al.
Publicado: (2021)

Xenotransplantation of Genetically Modified Neonatal Pig Islets Cures Diabetes in Baboons
por: Hawthorne, Wayne J., et al.
Publicado: (2022)

Severe Combined Immunodeficiency (SCID) in Canadian Children: A National Surveillance Study
por: Rozmus, Jacob, et al.
Publicado: (2013)

Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
por: Lebreton, Fanny, et al.
Publicado: (2019)

Geopolitics of governance: the impact of contrasting philosophies
por: Kakabadse, A, et al.
Publicado: (2001)

Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rg(null) RIP-DTR mice engrafted with human islets
por: Yang, Chaoxing, et al.
Publicado: (2015)

PEGylated Recombinant Adenosine Deaminase Maintains Detoxification and Lymphocyte Counts in Patients with ADA-SCID
por: Dorsey, Morna J., et al.
Publicado: (2023)

Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes
por: Campbell-Thompson, Martha, et al.
Publicado: (2021)

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease
por: Grizot, Sylvestre, et al.
Publicado: (2009)

CD11c(+) Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes
por: Sandor, Adam M., et al.
Publicado: (2019)

Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice
por: Vlad, George, et al.
Publicado: (2008)

Treatment of diabetic rats with encapsulated islets
por: Sweet, Ian R, et al.
Publicado: (2008)

Islet inflammation in type 2 diabetes
por: Böni-Schnetzler, Marianne, et al.
Publicado: (2019)

Pancreatic Islet Transcriptional Enhancers and Diabetes
por: Cebola, Inês
Publicado: (2019)

Commentary: Insulin-Producing Organoids Engineered From Islet and Amniotic Epithelial Cells to Treat Diabetes
por: Cobianchi, Lorenzo, et al.
Publicado: (2020)

Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain(null) Mice
por: Cai, Shanbao, et al.
Publicado: (2011)

The Non-Immune RIP-k(b) Mouse is a Useful Host for Islet Transplantation, as the Diabetes is Spontaneous, Mild and Predictable
por: Sutherland, Robyn M., et al.
Publicado: (2002)

Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice
Publicado: (1989)

Impaired Lymphocytes Development and Xenotransplantation of Gastrointestinal Tumor Cells in Prkdc-Null SCID Zebrafish Model()
por: Jung, In Hye, et al.
Publicado: (2016)

Correction to: PEGylated Recombinant Adenosine Deaminase Maintains Detoxification and Lymphocyte Counts in Patients with ADA-SCID
por: Dorsey, Morna J., et al.
Publicado: (2023)

Development of Type 1 Diabetes in Wild Bank Voles Associated With Islet Autoantibodies and the Novel Ljungan Virus
por: Niklasson, Bo, et al.
Publicado: (2003)

Implementation of SCID Screening in Denmark
por: Bækvad-Hansen, Marie, et al.
Publicado: (2021)

Membrane anchored IL-18 linked to constitutively active TLR4 and CD40 improves human T cell antitumor capacities for adoptive cell therapy
por: Blokon-Kogan, Dayana, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fejks8c824stvea3fol6bbc0go