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Exposure and risk assessment of urinary trans, trans-Muconic acid in school-age children in the vicinity of a petrochemical complex in Central Taiwan

School-age children living near large petrochemical factories may be at high risk of exposure to benzene released during manufacturing processes. We aimed to investigate the urinary concentrations of trans, trans-muconic acid (t,t-MA) in school-age children living near a petrochemical complex and to...

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Autores principales: Cheng, Po-Keng, Ponnusamy, Vinoth Kumar, Prakasham, Karthikeyan, Huang, Hsin-I, Chang, Wan-Ting, Huang, Po-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507417/
https://www.ncbi.nlm.nih.gov/pubmed/37732090
http://dx.doi.org/10.3389/fpubh.2023.1234823
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author Cheng, Po-Keng
Ponnusamy, Vinoth Kumar
Prakasham, Karthikeyan
Huang, Hsin-I
Chang, Wan-Ting
Huang, Po-Chin
author_facet Cheng, Po-Keng
Ponnusamy, Vinoth Kumar
Prakasham, Karthikeyan
Huang, Hsin-I
Chang, Wan-Ting
Huang, Po-Chin
author_sort Cheng, Po-Keng
collection PubMed
description School-age children living near large petrochemical factories may be at high risk of exposure to benzene released during manufacturing processes. We aimed to investigate the urinary concentrations of trans, trans-muconic acid (t,t-MA) in school-age children living near a petrochemical complex and to estimate their cumulative risk of benzene exposure. We examined an established cohort (Taiwan Petrochemical Complex Cohort for Children, TPE3C) of school-age children (aged 6–13 years) who lived near large petrochemical factories in central Taiwan between October 2013 and September 2014. The cohort comprised 297 children from five elementary schools, namely S.-C. Branch (n = 63, school A, ~0.9 km), F.-A. (n = 51, school B, ~2.7 km), C.-T. (n = 63, school C, ~5.5 km), M.-L. (n = 54, school D, ~6.9 km), and L.-F. (n = 66, school E, ~8.6 km). We analyzed the urinary t,t-MA levels of each participant and estimated their daily intake of benzene. We also performed multiple regression analysis to investigate potential risk factors for a high urinary t,t-MA level in the study cohort. The median urinary t,t-MA levels and median estimated benzene daily intake of the children from each school were as follows: school A, 64.07 ng/mL, 11.13 μg/kg/day; school B, 61.01 ng/mL, 15.32 μg/kg/day; school C, 59.38 ng/mL, 14.81 μg/kg/day; school D, 42.35 ng/mL, 11.67 μg/kg/day; school E, undetected, 0.14 μg/kg/day. The distance between a school and a petrochemical complex (greater distance: β = −0.26, 95% confidence interval [CI] = −0.52 to 0.00, p = 0.053), and the age of the children (older age: β = −3.44, 95% CI = −5.90 to −1.46, p < 0.001) were identified as potential risk factors. After confounders were adjusted for, the creatinine adjusted urinary t,t-MA levels of the school-age children tended to be lower when the distance between their school and a petrochemical complex was greater.
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spelling pubmed-105074172023-09-20 Exposure and risk assessment of urinary trans, trans-Muconic acid in school-age children in the vicinity of a petrochemical complex in Central Taiwan Cheng, Po-Keng Ponnusamy, Vinoth Kumar Prakasham, Karthikeyan Huang, Hsin-I Chang, Wan-Ting Huang, Po-Chin Front Public Health Public Health School-age children living near large petrochemical factories may be at high risk of exposure to benzene released during manufacturing processes. We aimed to investigate the urinary concentrations of trans, trans-muconic acid (t,t-MA) in school-age children living near a petrochemical complex and to estimate their cumulative risk of benzene exposure. We examined an established cohort (Taiwan Petrochemical Complex Cohort for Children, TPE3C) of school-age children (aged 6–13 years) who lived near large petrochemical factories in central Taiwan between October 2013 and September 2014. The cohort comprised 297 children from five elementary schools, namely S.-C. Branch (n = 63, school A, ~0.9 km), F.-A. (n = 51, school B, ~2.7 km), C.-T. (n = 63, school C, ~5.5 km), M.-L. (n = 54, school D, ~6.9 km), and L.-F. (n = 66, school E, ~8.6 km). We analyzed the urinary t,t-MA levels of each participant and estimated their daily intake of benzene. We also performed multiple regression analysis to investigate potential risk factors for a high urinary t,t-MA level in the study cohort. The median urinary t,t-MA levels and median estimated benzene daily intake of the children from each school were as follows: school A, 64.07 ng/mL, 11.13 μg/kg/day; school B, 61.01 ng/mL, 15.32 μg/kg/day; school C, 59.38 ng/mL, 14.81 μg/kg/day; school D, 42.35 ng/mL, 11.67 μg/kg/day; school E, undetected, 0.14 μg/kg/day. The distance between a school and a petrochemical complex (greater distance: β = −0.26, 95% confidence interval [CI] = −0.52 to 0.00, p = 0.053), and the age of the children (older age: β = −3.44, 95% CI = −5.90 to −1.46, p < 0.001) were identified as potential risk factors. After confounders were adjusted for, the creatinine adjusted urinary t,t-MA levels of the school-age children tended to be lower when the distance between their school and a petrochemical complex was greater. Frontiers Media S.A. 2023-09-04 /pmc/articles/PMC10507417/ /pubmed/37732090 http://dx.doi.org/10.3389/fpubh.2023.1234823 Text en Copyright © 2023 Cheng, Ponnusamy, Prakasham, Huang, Chang and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Cheng, Po-Keng
Ponnusamy, Vinoth Kumar
Prakasham, Karthikeyan
Huang, Hsin-I
Chang, Wan-Ting
Huang, Po-Chin
Exposure and risk assessment of urinary trans, trans-Muconic acid in school-age children in the vicinity of a petrochemical complex in Central Taiwan
title Exposure and risk assessment of urinary trans, trans-Muconic acid in school-age children in the vicinity of a petrochemical complex in Central Taiwan
title_full Exposure and risk assessment of urinary trans, trans-Muconic acid in school-age children in the vicinity of a petrochemical complex in Central Taiwan
title_fullStr Exposure and risk assessment of urinary trans, trans-Muconic acid in school-age children in the vicinity of a petrochemical complex in Central Taiwan
title_full_unstemmed Exposure and risk assessment of urinary trans, trans-Muconic acid in school-age children in the vicinity of a petrochemical complex in Central Taiwan
title_short Exposure and risk assessment of urinary trans, trans-Muconic acid in school-age children in the vicinity of a petrochemical complex in Central Taiwan
title_sort exposure and risk assessment of urinary trans, trans-muconic acid in school-age children in the vicinity of a petrochemical complex in central taiwan
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507417/
https://www.ncbi.nlm.nih.gov/pubmed/37732090
http://dx.doi.org/10.3389/fpubh.2023.1234823
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