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Comparative study of the plasma pharmacokinetics and tissue residues of trimethoprim in silky fowls and 817 broilers after single oral administration

A comparative study was performed to investigate the differences in plasma pharmacokinetics (PKs) and tissue residues of trimethoprim (TMP) between silky fowls and 817 broilers. The 2 breeds of chickens received compound sulfadiazine suspension by gavage at 20 mg/kg (measured as TMP). Blood and tiss...

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Autores principales: Hu, HuiYu, Qiu, JinHua, Li, RuoNan, Li, Dong, Wang, QianYong, Wang, QuanXi, Ma, YuFang, Yang, Wen, Xu, Rui, Liu, LingLing, Su, Yue, Song, HuiHui, Yang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507437/
https://www.ncbi.nlm.nih.gov/pubmed/37717479
http://dx.doi.org/10.1016/j.psj.2023.103060
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author Hu, HuiYu
Qiu, JinHua
Li, RuoNan
Li, Dong
Wang, QianYong
Wang, QuanXi
Ma, YuFang
Yang, Wen
Xu, Rui
Liu, LingLing
Su, Yue
Song, HuiHui
Yang, Bo
author_facet Hu, HuiYu
Qiu, JinHua
Li, RuoNan
Li, Dong
Wang, QianYong
Wang, QuanXi
Ma, YuFang
Yang, Wen
Xu, Rui
Liu, LingLing
Su, Yue
Song, HuiHui
Yang, Bo
author_sort Hu, HuiYu
collection PubMed
description A comparative study was performed to investigate the differences in plasma pharmacokinetics (PKs) and tissue residues of trimethoprim (TMP) between silky fowls and 817 broilers. The 2 breeds of chickens received compound sulfadiazine suspension by gavage at 20 mg/kg (measured as TMP). Blood and tissue samples were collected at predetermined time points. The concentrations of TMP in plasma and tissue samples were determined by a validated high-performance liquid chromatography (HPLC) method. The plasma concentration-time data were subjected to noncompartment analysis by WinNonlin program (Pharsight Co., Mountain View, CA). The mean plasma concentrations of TMP in silky fowls were significantly lower than those in 817 broilers at all time-points. Significant differences were also observed between silky fowls and 817 broilers in maximum concentration (C(max)), area under the curve from time 0 to 24 h (AUC(0 → 24 h)), apparent volume of distribution (V(d)), and total body clearance (Cl(B)). Silky fowls had significantly higher muscle TMP concentrations and longer tissue residual time than 817 broilers. The tissue concentration of TMP followed the order of leg muscle > breast muscle > liver, which was obviously different from that of 817 broilers. The half-lives of TMP in the leg muscle, breast muscle, and liver of silky fowls were 31.42, 10.78, and 0.38 d, respectively. The current withdrawal time (WDT) was not sufficient to prevent violative residues of TMP in the edible tissues of silky fowls, and a WDT much longer than 8 d might be required.
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spelling pubmed-105074372023-09-20 Comparative study of the plasma pharmacokinetics and tissue residues of trimethoprim in silky fowls and 817 broilers after single oral administration Hu, HuiYu Qiu, JinHua Li, RuoNan Li, Dong Wang, QianYong Wang, QuanXi Ma, YuFang Yang, Wen Xu, Rui Liu, LingLing Su, Yue Song, HuiHui Yang, Bo Poult Sci MICROBIOLOGY AND FOOD SAFETY A comparative study was performed to investigate the differences in plasma pharmacokinetics (PKs) and tissue residues of trimethoprim (TMP) between silky fowls and 817 broilers. The 2 breeds of chickens received compound sulfadiazine suspension by gavage at 20 mg/kg (measured as TMP). Blood and tissue samples were collected at predetermined time points. The concentrations of TMP in plasma and tissue samples were determined by a validated high-performance liquid chromatography (HPLC) method. The plasma concentration-time data were subjected to noncompartment analysis by WinNonlin program (Pharsight Co., Mountain View, CA). The mean plasma concentrations of TMP in silky fowls were significantly lower than those in 817 broilers at all time-points. Significant differences were also observed between silky fowls and 817 broilers in maximum concentration (C(max)), area under the curve from time 0 to 24 h (AUC(0 → 24 h)), apparent volume of distribution (V(d)), and total body clearance (Cl(B)). Silky fowls had significantly higher muscle TMP concentrations and longer tissue residual time than 817 broilers. The tissue concentration of TMP followed the order of leg muscle > breast muscle > liver, which was obviously different from that of 817 broilers. The half-lives of TMP in the leg muscle, breast muscle, and liver of silky fowls were 31.42, 10.78, and 0.38 d, respectively. The current withdrawal time (WDT) was not sufficient to prevent violative residues of TMP in the edible tissues of silky fowls, and a WDT much longer than 8 d might be required. Elsevier 2023-08-23 /pmc/articles/PMC10507437/ /pubmed/37717479 http://dx.doi.org/10.1016/j.psj.2023.103060 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle MICROBIOLOGY AND FOOD SAFETY
Hu, HuiYu
Qiu, JinHua
Li, RuoNan
Li, Dong
Wang, QianYong
Wang, QuanXi
Ma, YuFang
Yang, Wen
Xu, Rui
Liu, LingLing
Su, Yue
Song, HuiHui
Yang, Bo
Comparative study of the plasma pharmacokinetics and tissue residues of trimethoprim in silky fowls and 817 broilers after single oral administration
title Comparative study of the plasma pharmacokinetics and tissue residues of trimethoprim in silky fowls and 817 broilers after single oral administration
title_full Comparative study of the plasma pharmacokinetics and tissue residues of trimethoprim in silky fowls and 817 broilers after single oral administration
title_fullStr Comparative study of the plasma pharmacokinetics and tissue residues of trimethoprim in silky fowls and 817 broilers after single oral administration
title_full_unstemmed Comparative study of the plasma pharmacokinetics and tissue residues of trimethoprim in silky fowls and 817 broilers after single oral administration
title_short Comparative study of the plasma pharmacokinetics and tissue residues of trimethoprim in silky fowls and 817 broilers after single oral administration
title_sort comparative study of the plasma pharmacokinetics and tissue residues of trimethoprim in silky fowls and 817 broilers after single oral administration
topic MICROBIOLOGY AND FOOD SAFETY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507437/
https://www.ncbi.nlm.nih.gov/pubmed/37717479
http://dx.doi.org/10.1016/j.psj.2023.103060
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