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Novel deformable self-assembled magnetic anastomosis ring for endoscopic treatment of colonic stenosis via natural orifice

BACKGROUND: Although endoscope-assisted magnetic compression anastomosis has already been reported for colonic anastomosis, there is no report on a single-approach operation using the natural orifice. AIM: To design a deformable self-assembled magnetic anastomosis ring (DSAMAR) for colonic anastomos...

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Autores principales: Zhang, Miao-Miao, Zhao, Guang-Bin, Zhang, Han-Zhi, Xu, Shu-Qin, Shi, Ai-Hua, Mao, Jian-Qi, Gai, Jing-Ci, Zhang, Yu-Han, Ma, Jia, Li, Yun, Lyu, Yi, Yan, Xiao-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507506/
https://www.ncbi.nlm.nih.gov/pubmed/37731993
http://dx.doi.org/10.3748/wjg.v29.i33.5005
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author Zhang, Miao-Miao
Zhao, Guang-Bin
Zhang, Han-Zhi
Xu, Shu-Qin
Shi, Ai-Hua
Mao, Jian-Qi
Gai, Jing-Ci
Zhang, Yu-Han
Ma, Jia
Li, Yun
Lyu, Yi
Yan, Xiao-Peng
author_facet Zhang, Miao-Miao
Zhao, Guang-Bin
Zhang, Han-Zhi
Xu, Shu-Qin
Shi, Ai-Hua
Mao, Jian-Qi
Gai, Jing-Ci
Zhang, Yu-Han
Ma, Jia
Li, Yun
Lyu, Yi
Yan, Xiao-Peng
author_sort Zhang, Miao-Miao
collection PubMed
description BACKGROUND: Although endoscope-assisted magnetic compression anastomosis has already been reported for colonic anastomosis, there is no report on a single-approach operation using the natural orifice. AIM: To design a deformable self-assembled magnetic anastomosis ring (DSAMAR) for colonic anastomosis for use in single-approach operation and evaluate its feasibility and safety through animal experiments. METHODS: The animal model for colonic stenosis was prepared by partial colonic ligation in eight beagles. The magnetic compression anastomosis of their colonic stricture was performed by endoscopically assisted transanal implantation of the DSAMAR. The anastomotic specimen, obtained 2 wk after the operation, was observed by both the naked eye and a light microscope. RESULTS: The DSAMAR was successfully inserted into the proximal end of colon stenosis through the anus. The DSAMAR of seven dogs was successfully transformed into rings, while that of the remaining dog was removed after the first deformation failed. The rings were successfully retransformed after optimization. All animals underwent colonic anastomosis using the DSAMAR. No device-related or procedure-related adverse events were observed. The colostomy specimens of the experimental dogs were obtained 2 wk after the operation. Both gross and histological observations showed good anastomotic healing. CONCLUSION: The DSAMAR is a safe and feasible option for the treatment of colon stenosis. Its specific deformation and self-assembly capability maximize the applicability of the minimally invasive treatment.
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spelling pubmed-105075062023-09-20 Novel deformable self-assembled magnetic anastomosis ring for endoscopic treatment of colonic stenosis via natural orifice Zhang, Miao-Miao Zhao, Guang-Bin Zhang, Han-Zhi Xu, Shu-Qin Shi, Ai-Hua Mao, Jian-Qi Gai, Jing-Ci Zhang, Yu-Han Ma, Jia Li, Yun Lyu, Yi Yan, Xiao-Peng World J Gastroenterol Basic Study BACKGROUND: Although endoscope-assisted magnetic compression anastomosis has already been reported for colonic anastomosis, there is no report on a single-approach operation using the natural orifice. AIM: To design a deformable self-assembled magnetic anastomosis ring (DSAMAR) for colonic anastomosis for use in single-approach operation and evaluate its feasibility and safety through animal experiments. METHODS: The animal model for colonic stenosis was prepared by partial colonic ligation in eight beagles. The magnetic compression anastomosis of their colonic stricture was performed by endoscopically assisted transanal implantation of the DSAMAR. The anastomotic specimen, obtained 2 wk after the operation, was observed by both the naked eye and a light microscope. RESULTS: The DSAMAR was successfully inserted into the proximal end of colon stenosis through the anus. The DSAMAR of seven dogs was successfully transformed into rings, while that of the remaining dog was removed after the first deformation failed. The rings were successfully retransformed after optimization. All animals underwent colonic anastomosis using the DSAMAR. No device-related or procedure-related adverse events were observed. The colostomy specimens of the experimental dogs were obtained 2 wk after the operation. Both gross and histological observations showed good anastomotic healing. CONCLUSION: The DSAMAR is a safe and feasible option for the treatment of colon stenosis. Its specific deformation and self-assembly capability maximize the applicability of the minimally invasive treatment. Baishideng Publishing Group Inc 2023-09-07 2023-09-07 /pmc/articles/PMC10507506/ /pubmed/37731993 http://dx.doi.org/10.3748/wjg.v29.i33.5005 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Basic Study
Zhang, Miao-Miao
Zhao, Guang-Bin
Zhang, Han-Zhi
Xu, Shu-Qin
Shi, Ai-Hua
Mao, Jian-Qi
Gai, Jing-Ci
Zhang, Yu-Han
Ma, Jia
Li, Yun
Lyu, Yi
Yan, Xiao-Peng
Novel deformable self-assembled magnetic anastomosis ring for endoscopic treatment of colonic stenosis via natural orifice
title Novel deformable self-assembled magnetic anastomosis ring for endoscopic treatment of colonic stenosis via natural orifice
title_full Novel deformable self-assembled magnetic anastomosis ring for endoscopic treatment of colonic stenosis via natural orifice
title_fullStr Novel deformable self-assembled magnetic anastomosis ring for endoscopic treatment of colonic stenosis via natural orifice
title_full_unstemmed Novel deformable self-assembled magnetic anastomosis ring for endoscopic treatment of colonic stenosis via natural orifice
title_short Novel deformable self-assembled magnetic anastomosis ring for endoscopic treatment of colonic stenosis via natural orifice
title_sort novel deformable self-assembled magnetic anastomosis ring for endoscopic treatment of colonic stenosis via natural orifice
topic Basic Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507506/
https://www.ncbi.nlm.nih.gov/pubmed/37731993
http://dx.doi.org/10.3748/wjg.v29.i33.5005
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