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The Effects of Risperidone on Cognition in People With Autism Spectrum Disorder: A Systematic Review
Autism spectrum disorder is made up of several disorders, which include autism, Asperger syndrome, and pervasive developmental disorder. Boys are four times more likely to be diagnosed than girls with autism spectrum disorder, and symptoms usually become apparent by the age of three. Autism spectrum...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507658/ https://www.ncbi.nlm.nih.gov/pubmed/37731686 http://dx.doi.org/10.7759/cureus.45524 |
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author | Hutchinson, Jhenelle Folawemi, Oluwa Bittla, Parikshit Kaur, Simran Sojitra, Vani Zahra, Anam Khan, Safeera |
author_facet | Hutchinson, Jhenelle Folawemi, Oluwa Bittla, Parikshit Kaur, Simran Sojitra, Vani Zahra, Anam Khan, Safeera |
author_sort | Hutchinson, Jhenelle |
collection | PubMed |
description | Autism spectrum disorder is made up of several disorders, which include autism, Asperger syndrome, and pervasive developmental disorder. Boys are four times more likely to be diagnosed than girls with autism spectrum disorder, and symptoms usually become apparent by the age of three. Autism spectrum disorders’ core characteristic features are abnormal interaction, impairment in communication, and stereotyped behaviors with restricted activities and interests. There are also non-core features associated with autism spectrum disorder, and these are aggression, self-injurious behavior, and tantrums. To date, there is no one drug approved to treat the core symptoms of autism spectrum disorder, but antipsychotic drugs such as risperidone have been shown to be effective at treating both core and non-core symptoms in controlled trials using multiple behavioral rating scales such as the Aberrant Behavioral Checklist subscale, the Clinical Global Impression Improvement Scale, the Ritvo-Freeman Real Life Scale, the Children’s Yale-Brown Obsessive Compulsive Scale, the Vineland Adaptive Behavior Scale, and the Social Withdrawal Subscale. The safety, efficacy, acceptability, and tolerability of risperidone were assessed in these studies, and weight gain was a common side effect observed, but the outcome was usually mild and self-limiting. The effect of risperidone on cognition was explored in this article. The studies selected for this article were of small sample size and short duration, which presented limitations for treatment with risperidone and an area that needs to be explored further for its contribution to clinical practice. |
format | Online Article Text |
id | pubmed-10507658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-105076582023-09-20 The Effects of Risperidone on Cognition in People With Autism Spectrum Disorder: A Systematic Review Hutchinson, Jhenelle Folawemi, Oluwa Bittla, Parikshit Kaur, Simran Sojitra, Vani Zahra, Anam Khan, Safeera Cureus Psychiatry Autism spectrum disorder is made up of several disorders, which include autism, Asperger syndrome, and pervasive developmental disorder. Boys are four times more likely to be diagnosed than girls with autism spectrum disorder, and symptoms usually become apparent by the age of three. Autism spectrum disorders’ core characteristic features are abnormal interaction, impairment in communication, and stereotyped behaviors with restricted activities and interests. There are also non-core features associated with autism spectrum disorder, and these are aggression, self-injurious behavior, and tantrums. To date, there is no one drug approved to treat the core symptoms of autism spectrum disorder, but antipsychotic drugs such as risperidone have been shown to be effective at treating both core and non-core symptoms in controlled trials using multiple behavioral rating scales such as the Aberrant Behavioral Checklist subscale, the Clinical Global Impression Improvement Scale, the Ritvo-Freeman Real Life Scale, the Children’s Yale-Brown Obsessive Compulsive Scale, the Vineland Adaptive Behavior Scale, and the Social Withdrawal Subscale. The safety, efficacy, acceptability, and tolerability of risperidone were assessed in these studies, and weight gain was a common side effect observed, but the outcome was usually mild and self-limiting. The effect of risperidone on cognition was explored in this article. The studies selected for this article were of small sample size and short duration, which presented limitations for treatment with risperidone and an area that needs to be explored further for its contribution to clinical practice. Cureus 2023-09-19 /pmc/articles/PMC10507658/ /pubmed/37731686 http://dx.doi.org/10.7759/cureus.45524 Text en Copyright © 2023, Hutchinson et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Psychiatry Hutchinson, Jhenelle Folawemi, Oluwa Bittla, Parikshit Kaur, Simran Sojitra, Vani Zahra, Anam Khan, Safeera The Effects of Risperidone on Cognition in People With Autism Spectrum Disorder: A Systematic Review |
title | The Effects of Risperidone on Cognition in People With Autism Spectrum Disorder: A Systematic Review |
title_full | The Effects of Risperidone on Cognition in People With Autism Spectrum Disorder: A Systematic Review |
title_fullStr | The Effects of Risperidone on Cognition in People With Autism Spectrum Disorder: A Systematic Review |
title_full_unstemmed | The Effects of Risperidone on Cognition in People With Autism Spectrum Disorder: A Systematic Review |
title_short | The Effects of Risperidone on Cognition in People With Autism Spectrum Disorder: A Systematic Review |
title_sort | effects of risperidone on cognition in people with autism spectrum disorder: a systematic review |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507658/ https://www.ncbi.nlm.nih.gov/pubmed/37731686 http://dx.doi.org/10.7759/cureus.45524 |
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