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Periodic ethanol supply as a path toward unlimited lifespan of Caenorhabditis elegans dauer larvae

The dauer larva is a specialized stage of worm development optimized for survival under harsh conditions that have been used as a model for stress resistance, metabolic adaptations, and longevity. Recent findings suggest that the dauer larva of Caenorhabditis elegans may utilize external ethanol as...

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Autores principales: Zhang, Xingyu, Penkov, Sider, Kurzchalia, Teymuras V., Zaburdaev, Vasily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507685/
https://www.ncbi.nlm.nih.gov/pubmed/37731965
http://dx.doi.org/10.3389/fragi.2023.1031161
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author Zhang, Xingyu
Penkov, Sider
Kurzchalia, Teymuras V.
Zaburdaev, Vasily
author_facet Zhang, Xingyu
Penkov, Sider
Kurzchalia, Teymuras V.
Zaburdaev, Vasily
author_sort Zhang, Xingyu
collection PubMed
description The dauer larva is a specialized stage of worm development optimized for survival under harsh conditions that have been used as a model for stress resistance, metabolic adaptations, and longevity. Recent findings suggest that the dauer larva of Caenorhabditis elegans may utilize external ethanol as an energy source to extend their lifespan. It was shown that while ethanol may serve as an effectively infinite source of energy, some toxic compounds accumulating as byproducts of its metabolism may lead to the damage of mitochondria and thus limit the lifespan of larvae. A minimal mathematical model was proposed to explain the connection between the lifespan of a dauer larva and its ethanol metabolism. To explore theoretically if it is possible to extend even further the lifespan of dauer larvae, we incorporated two natural mechanisms describing the recovery of damaged mitochondria and elimination of toxic compounds, which were previously omitted in the model. Numerical simulations of the revised model suggested that while the ethanol concentration is constant, the lifespan still stays limited. However, if ethanol is supplied periodically, with a suitable frequency and amplitude, the dauer could survive as long as we observe the system. Analytical methods further help to explain how feeding frequency and amplitude affect lifespan extension. Based on the comparison of the model with experimental data for fixed ethanol concentration, we proposed the range of feeding protocols that could lead to even longer dauer survival and it can be tested experimentally.
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spelling pubmed-105076852023-09-20 Periodic ethanol supply as a path toward unlimited lifespan of Caenorhabditis elegans dauer larvae Zhang, Xingyu Penkov, Sider Kurzchalia, Teymuras V. Zaburdaev, Vasily Front Aging Aging The dauer larva is a specialized stage of worm development optimized for survival under harsh conditions that have been used as a model for stress resistance, metabolic adaptations, and longevity. Recent findings suggest that the dauer larva of Caenorhabditis elegans may utilize external ethanol as an energy source to extend their lifespan. It was shown that while ethanol may serve as an effectively infinite source of energy, some toxic compounds accumulating as byproducts of its metabolism may lead to the damage of mitochondria and thus limit the lifespan of larvae. A minimal mathematical model was proposed to explain the connection between the lifespan of a dauer larva and its ethanol metabolism. To explore theoretically if it is possible to extend even further the lifespan of dauer larvae, we incorporated two natural mechanisms describing the recovery of damaged mitochondria and elimination of toxic compounds, which were previously omitted in the model. Numerical simulations of the revised model suggested that while the ethanol concentration is constant, the lifespan still stays limited. However, if ethanol is supplied periodically, with a suitable frequency and amplitude, the dauer could survive as long as we observe the system. Analytical methods further help to explain how feeding frequency and amplitude affect lifespan extension. Based on the comparison of the model with experimental data for fixed ethanol concentration, we proposed the range of feeding protocols that could lead to even longer dauer survival and it can be tested experimentally. Frontiers Media S.A. 2023-09-05 /pmc/articles/PMC10507685/ /pubmed/37731965 http://dx.doi.org/10.3389/fragi.2023.1031161 Text en Copyright © 2023 Zhang, Penkov, Kurzchalia and Zaburdaev. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Zhang, Xingyu
Penkov, Sider
Kurzchalia, Teymuras V.
Zaburdaev, Vasily
Periodic ethanol supply as a path toward unlimited lifespan of Caenorhabditis elegans dauer larvae
title Periodic ethanol supply as a path toward unlimited lifespan of Caenorhabditis elegans dauer larvae
title_full Periodic ethanol supply as a path toward unlimited lifespan of Caenorhabditis elegans dauer larvae
title_fullStr Periodic ethanol supply as a path toward unlimited lifespan of Caenorhabditis elegans dauer larvae
title_full_unstemmed Periodic ethanol supply as a path toward unlimited lifespan of Caenorhabditis elegans dauer larvae
title_short Periodic ethanol supply as a path toward unlimited lifespan of Caenorhabditis elegans dauer larvae
title_sort periodic ethanol supply as a path toward unlimited lifespan of caenorhabditis elegans dauer larvae
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507685/
https://www.ncbi.nlm.nih.gov/pubmed/37731965
http://dx.doi.org/10.3389/fragi.2023.1031161
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