The influence of methotrexate-related transporter and metabolizing enzyme gene polymorphisms on peri-engraftment syndrome and graft-versus-host disease after haplo-hematopoietic stem cell transplantation in pediatric patients with malignant hematological diseases

BACKGROUND: Methotrexate (MTX), utilized as a graft-versus-host disease (GvHD) prophylactic agent in allogeneic hematopoietic stem cell transplantation (allo-HSCT), has been proven to effectively decrease the occurrence of the peri-engraftment syndrome (Peri-ES) and acute GvHD (aGvHD). Changes in th...

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Detalles Bibliográficos
Autores principales: Ji, Qi, Zhang, Yongping, Hu, Yixin, Liu, Lixia, Cao, Shanbo, Gao, Li, Li, Bohan, Tian, Yuanyuan, Kong, Lingjun, Wu, Shuiyan, Ling, Jing, Xiao, Peifang, Lu, Jun, Li, Jie, Yao, Yanhua, Qin, Jiayue, Hu, Shaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507719/
https://www.ncbi.nlm.nih.gov/pubmed/37731501
http://dx.doi.org/10.3389/fimmu.2023.1229266

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