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CD39 molecule: a negative regulator expressed on T cells in patients with lung adenocarcinoma
INTRODUCTION: The function of cytotoxic cells may be impacted by CD39 expression on CD8-positive T lymphocytes, leading to an imbalance in tumor immunity. METHODS: We analyzed the correlation between the expression of CD39 on CD8-positive T lymphocytes and clinical information in 203 patients with l...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507747/ https://www.ncbi.nlm.nih.gov/pubmed/37732039 http://dx.doi.org/10.5114/aoms/170959 |
Sumario: | INTRODUCTION: The function of cytotoxic cells may be impacted by CD39 expression on CD8-positive T lymphocytes, leading to an imbalance in tumor immunity. METHODS: We analyzed the correlation between the expression of CD39 on CD8-positive T lymphocytes and clinical information in 203 patients with lung adenocarcinoma. RESULTS: The expression of CD39 on CD8-positive T lymphocytes was related to T stage, lymph node metastasis and distant metastasis. Furthermore, the CD39 expression reduced the secretion of antitumor cytokines, promoted PD-1 expression and decreased CD28 expression on CD8-positive T lymphocytes. CONCLUSIONS: This research demonstrated the potential value of CD39 on CD8-positive T lymphocytes as a negative regulator in cancer immunotherapy. |
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