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Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function

INTRODUCTION: For years, there has been an increase in the number of cases of chronic kidney disease (CKD) in human immunodeficiency virus (HIV)-infected patients. Renal dysfunction can be caused by direct effects of HIV on the kidneys but also of applied combined antiretroviral therapy (cART). Ther...

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Autores principales: Szymańska, Beata, Marchewka, Zofia, Knysz, Brygida, Piwowar, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507753/
https://www.ncbi.nlm.nih.gov/pubmed/37732028
http://dx.doi.org/10.5114/aoms/114635
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author Szymańska, Beata
Marchewka, Zofia
Knysz, Brygida
Piwowar, Agnieszka
author_facet Szymańska, Beata
Marchewka, Zofia
Knysz, Brygida
Piwowar, Agnieszka
author_sort Szymańska, Beata
collection PubMed
description INTRODUCTION: For years, there has been an increase in the number of cases of chronic kidney disease (CKD) in human immunodeficiency virus (HIV)-infected patients. Renal dysfunction can be caused by direct effects of HIV on the kidneys but also of applied combined antiretroviral therapy (cART). Therefore there is a need of renal function diagnosis to monitor the development of kidney disturbances. In this study the urinary levels of selected low molecular weight proteins (LMWP) in HIV-infected patients were measured and related to current CD4+ T lymphocyte (LT CD4+) count, the glomerular filtration rate (eGFR) value and the applied cART. MATERIAL AND METHODS: The levels of 5 LMWP – kidney injury molecule-1 (KIM-1), neutrophil gelatinase associated lipocalin (NGAL), glutathione S-transferase α (GST-α) and π (GST-π) isoenzymes and neopterin (NPT) – in urine were measured in HIV-infected patients and healthy controls by enzyme-linked immunosorbent assay. RESULTS: Taking into account the current LT CD4+ count, KIM-1, NGAL and GST-α showed statistically significant differences between groups with the CD4+ count < 500 and ≥ 500 cells (< 0.001). Depending on the eGFR, apart from KIM-1 and NGAL, NPT showed statistically significant differences in the investigated groups with normal and lower eGFR values (< 0.001). In terms of applied cART, the best parameters in the assessment of kidney damage were NGAL, GST-π and NPT (< 0.001). CONCLUSIONS: This research shows that the analyzed LMWP parameters are useful in the assessment of kidney damage in HIV patients during cART, especially NPT, NGAL and GST-π. However, future studies should be conducted on larger groups.
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spelling pubmed-105077532023-09-20 Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function Szymańska, Beata Marchewka, Zofia Knysz, Brygida Piwowar, Agnieszka Arch Med Sci Clinical Research INTRODUCTION: For years, there has been an increase in the number of cases of chronic kidney disease (CKD) in human immunodeficiency virus (HIV)-infected patients. Renal dysfunction can be caused by direct effects of HIV on the kidneys but also of applied combined antiretroviral therapy (cART). Therefore there is a need of renal function diagnosis to monitor the development of kidney disturbances. In this study the urinary levels of selected low molecular weight proteins (LMWP) in HIV-infected patients were measured and related to current CD4+ T lymphocyte (LT CD4+) count, the glomerular filtration rate (eGFR) value and the applied cART. MATERIAL AND METHODS: The levels of 5 LMWP – kidney injury molecule-1 (KIM-1), neutrophil gelatinase associated lipocalin (NGAL), glutathione S-transferase α (GST-α) and π (GST-π) isoenzymes and neopterin (NPT) – in urine were measured in HIV-infected patients and healthy controls by enzyme-linked immunosorbent assay. RESULTS: Taking into account the current LT CD4+ count, KIM-1, NGAL and GST-α showed statistically significant differences between groups with the CD4+ count < 500 and ≥ 500 cells (< 0.001). Depending on the eGFR, apart from KIM-1 and NGAL, NPT showed statistically significant differences in the investigated groups with normal and lower eGFR values (< 0.001). In terms of applied cART, the best parameters in the assessment of kidney damage were NGAL, GST-π and NPT (< 0.001). CONCLUSIONS: This research shows that the analyzed LMWP parameters are useful in the assessment of kidney damage in HIV patients during cART, especially NPT, NGAL and GST-π. However, future studies should be conducted on larger groups. Termedia Publishing House 2021-05-22 /pmc/articles/PMC10507753/ /pubmed/37732028 http://dx.doi.org/10.5114/aoms/114635 Text en Copyright: © 2021 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Szymańska, Beata
Marchewka, Zofia
Knysz, Brygida
Piwowar, Agnieszka
Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function
title Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function
title_full Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function
title_fullStr Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function
title_full_unstemmed Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function
title_short Selected biochemical parameters in the urine of HIV-infected patients in monitoring of kidney function
title_sort selected biochemical parameters in the urine of hiv-infected patients in monitoring of kidney function
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507753/
https://www.ncbi.nlm.nih.gov/pubmed/37732028
http://dx.doi.org/10.5114/aoms/114635
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