Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance

INTRODUCTION: To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7. METHODS: The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR. RESULTS: The area of spleen fibrosis in th...

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Autores principales: Lv, Yunfu, Li, Yejuan, Han, XiaoYu, Liu, Ning, Zeng, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507761/
https://www.ncbi.nlm.nih.gov/pubmed/37732054
http://dx.doi.org/10.5114/aoms/170910
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author Lv, Yunfu
Li, Yejuan
Han, XiaoYu
Liu, Ning
Zeng, Min
author_facet Lv, Yunfu
Li, Yejuan
Han, XiaoYu
Liu, Ning
Zeng, Min
author_sort Lv, Yunfu
collection PubMed
description INTRODUCTION: To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7. METHODS: The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR. RESULTS: The area of spleen fibrosis in the model group was significantly larger than that in the control group (p < 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group (p < 0.01). CONCLUSIONS: CXCL12-CXCR4/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism.
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spelling pubmed-105077612023-09-20 Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance Lv, Yunfu Li, Yejuan Han, XiaoYu Liu, Ning Zeng, Min Arch Med Sci Research Letter INTRODUCTION: To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7. METHODS: The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR. RESULTS: The area of spleen fibrosis in the model group was significantly larger than that in the control group (p < 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group (p < 0.01). CONCLUSIONS: CXCL12-CXCR4/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism. Termedia Publishing House 2023-08-25 /pmc/articles/PMC10507761/ /pubmed/37732054 http://dx.doi.org/10.5114/aoms/170910 Text en Copyright: © 2023 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Research Letter
Lv, Yunfu
Li, Yejuan
Han, XiaoYu
Liu, Ning
Zeng, Min
Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance
title Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance
title_full Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance
title_fullStr Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance
title_full_unstemmed Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance
title_short Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance
title_sort expression of cxcl12-cxcr4/cxcr7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507761/
https://www.ncbi.nlm.nih.gov/pubmed/37732054
http://dx.doi.org/10.5114/aoms/170910
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