Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people

INTRODUCTION: This study aimed to investigate the relationship of gene polymorphisms and fat mass (FM) in Chinese population. METHODS: Healthy males, premenopausal and postmenopausal women were recruited. Single Nucleotide Polymorphisms (SNPs) and FM were measured. RESULTS: The rs141206415 in the RA...

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Autores principales: Qi, Luyue, Zhang, Zhenlin, Hu, Weiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507778/
https://www.ncbi.nlm.nih.gov/pubmed/37732072
http://dx.doi.org/10.5114/aoms/170851
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author Qi, Luyue
Zhang, Zhenlin
Hu, Weiwei
author_facet Qi, Luyue
Zhang, Zhenlin
Hu, Weiwei
author_sort Qi, Luyue
collection PubMed
description INTRODUCTION: This study aimed to investigate the relationship of gene polymorphisms and fat mass (FM) in Chinese population. METHODS: Healthy males, premenopausal and postmenopausal women were recruited. Single Nucleotide Polymorphisms (SNPs) and FM were measured. RESULTS: The rs141206415 in the RASAL1 gene and rs144493374 in the PALLD gene were associated with trunk FM, and the rs4807023 in the PTPRS gene was associated with leg FM using Spearman correlation analysis. CONCLUSIONS: The results suggest that the RASAL1 gene and the PALLD gene might contribute to variability of trunk FM in healthy Chinese Han people. The PTPRS gene is potentially correlated with leg FM. Our findings provide a clue in fat metabolism.
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spelling pubmed-105077782023-09-20 Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people Qi, Luyue Zhang, Zhenlin Hu, Weiwei Arch Med Sci Research Letter INTRODUCTION: This study aimed to investigate the relationship of gene polymorphisms and fat mass (FM) in Chinese population. METHODS: Healthy males, premenopausal and postmenopausal women were recruited. Single Nucleotide Polymorphisms (SNPs) and FM were measured. RESULTS: The rs141206415 in the RASAL1 gene and rs144493374 in the PALLD gene were associated with trunk FM, and the rs4807023 in the PTPRS gene was associated with leg FM using Spearman correlation analysis. CONCLUSIONS: The results suggest that the RASAL1 gene and the PALLD gene might contribute to variability of trunk FM in healthy Chinese Han people. The PTPRS gene is potentially correlated with leg FM. Our findings provide a clue in fat metabolism. Termedia Publishing House 2023-08-25 /pmc/articles/PMC10507778/ /pubmed/37732072 http://dx.doi.org/10.5114/aoms/170851 Text en Copyright: © 2023 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Research Letter
Qi, Luyue
Zhang, Zhenlin
Hu, Weiwei
Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people
title Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people
title_full Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people
title_fullStr Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people
title_full_unstemmed Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people
title_short Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people
title_sort identification of gene polymorphisms associated with fat mass by genome-wide association study in chinese people
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507778/
https://www.ncbi.nlm.nih.gov/pubmed/37732072
http://dx.doi.org/10.5114/aoms/170851
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AT zhangzhenlin identificationofgenepolymorphismsassociatedwithfatmassbygenomewideassociationstudyinchinesepeople
AT huweiwei identificationofgenepolymorphismsassociatedwithfatmassbygenomewideassociationstudyinchinesepeople

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