The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study

INTRODUCTION: The aim of the study was to examine the association between frailty and osteoarthritis. METHODS: We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian randomizati...

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Detalles Bibliográficos
Autores principales: Huang, Guoxin, Qian, Da, Liu, Ying, Qu, Gaojing, Qian, Yuanyuan, Pei, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507783/
https://www.ncbi.nlm.nih.gov/pubmed/37732065
http://dx.doi.org/10.5114/aoms/171270
Descripción
Sumario:INTRODUCTION: The aim of the study was to examine the association between frailty and osteoarthritis. METHODS: We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian randomization (MR) study was used to explore the causal relationship between the two. RESULTS: In the cross-sectional study, logistic regression analysis showed that odds ratio (OR) (95% CI) value was 1.07 (1.05, 1.08). In the MR study, the inverse-variance weighting (IVW) results showed OR (95% CI) value of 1.69 (1.01–2.83). CONCLUSIONS: There is both a correlation and a causal relationship between frailty and osteoarthritis, and frailty may be a potentially better response than age to osteoarthritis.

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