Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity

Herein, we describe our efforts to identify sigma receptor 1 (S1R) ligands through a screening campaign on our in-house collection of piperidine/piperazine-based compounds. Our investigations led to the discovery of the potent compound 2-[4-(benzyl)-1-piperidin-1-yl]-1-4-(4-phenylpiperazin-1-yl)etha...

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Detalles Bibliográficos
Autores principales: De Luca, Laura, Lombardo, Lisa, Mirabile, Salvatore, Marrazzo, Agostino, Dichiara, Maria, Cosentino, Giuseppe, Amata, Emanuele, Gitto, Rosaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507793/
https://www.ncbi.nlm.nih.gov/pubmed/37731701
http://dx.doi.org/10.1039/d3md00291h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507793/
https://www.ncbi.nlm.nih.gov/pubmed/37731701
http://dx.doi.org/10.1039/d3md00291h

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