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Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells

The combination of compounds with complementary bioactivities into hybrid molecules is an emerging concept in drug discovery. In this study, we aimed to synthesize new hybrid compounds based on p53-MDM2/X protein–protein interaction spiropyrazoline oxindole-based inhibitors and ataxia telangiectasia...

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Detalles Bibliográficos
Autores principales:	Girst, Gábor, Lopes, Elizabeth A., Gonçalves, Lídia M., Espadinha, Margarida, Kúsz, Norbert, Wang, Hui-Chun, Santos, Maria M. M., Hunyadi, Attila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507806/ https://www.ncbi.nlm.nih.gov/pubmed/37731691 http://dx.doi.org/10.1039/d3md00251a

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