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Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas?
After a period of unprecedented progress against malaria in the 2000s, halving the global disease burden by 2015, gains overall in sub-Saharan Africa have slowed and even reversed in some places, beginning well before the COVID-19 pandemic. The highly effective drugs, treated nets, and diagnostics t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507840/ https://www.ncbi.nlm.nih.gov/pubmed/37726804 http://dx.doi.org/10.1186/s12936-023-04714-z |
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author | Gelband, Hellen Carshon-Marsh, Ronald Ansumana, Rashid Swaray, Ibrahim Bob Pandey, Arjun Aimone, Ashley Bogoch, Isaac Eikelboom, John Jha, Prabhat |
author_facet | Gelband, Hellen Carshon-Marsh, Ronald Ansumana, Rashid Swaray, Ibrahim Bob Pandey, Arjun Aimone, Ashley Bogoch, Isaac Eikelboom, John Jha, Prabhat |
author_sort | Gelband, Hellen |
collection | PubMed |
description | After a period of unprecedented progress against malaria in the 2000s, halving the global disease burden by 2015, gains overall in sub-Saharan Africa have slowed and even reversed in some places, beginning well before the COVID-19 pandemic. The highly effective drugs, treated nets, and diagnostics that fueled the initial progress all face some threats to their effectiveness, and global funding to maintain and increase their use over the long term is not guaranteed. Malaria vaccines are among the most promising new interventions that could accelerate the elimination of malaria. Vaccines are still in early stages of rollout in children, the age group (along with pregnant women) that has been the focus of malaria strategies for a century. At the same time, over the past decade, a case has been made, based largely on evidence from verbal autopsies in at least a few high-transmission areas, that the malaria death rate among adults has been greatly underestimated. Could vaccinating adults help to bring down the adult malaria mortality rate, contribute to reduced transmission, or both? A randomized trial of a malaria vaccine is proposed in Sierra Leone, a highly endemic setting, to shed light on this proposition. |
format | Online Article Text |
id | pubmed-10507840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105078402023-09-20 Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? Gelband, Hellen Carshon-Marsh, Ronald Ansumana, Rashid Swaray, Ibrahim Bob Pandey, Arjun Aimone, Ashley Bogoch, Isaac Eikelboom, John Jha, Prabhat Malar J Perspective After a period of unprecedented progress against malaria in the 2000s, halving the global disease burden by 2015, gains overall in sub-Saharan Africa have slowed and even reversed in some places, beginning well before the COVID-19 pandemic. The highly effective drugs, treated nets, and diagnostics that fueled the initial progress all face some threats to their effectiveness, and global funding to maintain and increase their use over the long term is not guaranteed. Malaria vaccines are among the most promising new interventions that could accelerate the elimination of malaria. Vaccines are still in early stages of rollout in children, the age group (along with pregnant women) that has been the focus of malaria strategies for a century. At the same time, over the past decade, a case has been made, based largely on evidence from verbal autopsies in at least a few high-transmission areas, that the malaria death rate among adults has been greatly underestimated. Could vaccinating adults help to bring down the adult malaria mortality rate, contribute to reduced transmission, or both? A randomized trial of a malaria vaccine is proposed in Sierra Leone, a highly endemic setting, to shed light on this proposition. BioMed Central 2023-09-19 /pmc/articles/PMC10507840/ /pubmed/37726804 http://dx.doi.org/10.1186/s12936-023-04714-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Perspective Gelband, Hellen Carshon-Marsh, Ronald Ansumana, Rashid Swaray, Ibrahim Bob Pandey, Arjun Aimone, Ashley Bogoch, Isaac Eikelboom, John Jha, Prabhat Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title | Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title_full | Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title_fullStr | Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title_full_unstemmed | Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title_short | Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title_sort | could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507840/ https://www.ncbi.nlm.nih.gov/pubmed/37726804 http://dx.doi.org/10.1186/s12936-023-04714-z |
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