TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans

The Transforming Growth Factor-β (TGF-β) superfamily of signaling molecules plays critical roles in development, differentiation, homeostasis, and disease. Due to the conservation of these ligands and their signaling pathways, genetic studies in invertebrate systems including the nematode Caenorhabd...

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Autores principales: Yamamoto, Katerina K., Savage-Dunn, Cathy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507863/
https://www.ncbi.nlm.nih.gov/pubmed/37732316
http://dx.doi.org/10.3389/fgene.2023.1220068
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author Yamamoto, Katerina K.
Savage-Dunn, Cathy
author_facet Yamamoto, Katerina K.
Savage-Dunn, Cathy
author_sort Yamamoto, Katerina K.
collection PubMed
description The Transforming Growth Factor-β (TGF-β) superfamily of signaling molecules plays critical roles in development, differentiation, homeostasis, and disease. Due to the conservation of these ligands and their signaling pathways, genetic studies in invertebrate systems including the nematode Caenorhabditis elegans have been instrumental in identifying signaling mechanisms. C. elegans is also a premier organism for research in longevity and healthy aging. Here we summarize current knowledge on the roles of TGF-β signaling in aging and immunity.
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spelling pubmed-105078632023-09-20 TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans Yamamoto, Katerina K. Savage-Dunn, Cathy Front Genet Genetics The Transforming Growth Factor-β (TGF-β) superfamily of signaling molecules plays critical roles in development, differentiation, homeostasis, and disease. Due to the conservation of these ligands and their signaling pathways, genetic studies in invertebrate systems including the nematode Caenorhabditis elegans have been instrumental in identifying signaling mechanisms. C. elegans is also a premier organism for research in longevity and healthy aging. Here we summarize current knowledge on the roles of TGF-β signaling in aging and immunity. Frontiers Media S.A. 2023-09-05 /pmc/articles/PMC10507863/ /pubmed/37732316 http://dx.doi.org/10.3389/fgene.2023.1220068 Text en Copyright © 2023 Yamamoto and Savage-Dunn. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Yamamoto, Katerina K.
Savage-Dunn, Cathy
TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans
title TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans
title_full TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans
title_fullStr TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans
title_full_unstemmed TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans
title_short TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans
title_sort tgf-β pathways in aging and immunity: lessons from caenorhabditis elegans
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507863/
https://www.ncbi.nlm.nih.gov/pubmed/37732316
http://dx.doi.org/10.3389/fgene.2023.1220068
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