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Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population
BACKGROUND: Physiological glycated hemoglobin (HbA1c) values in each trimester are not well defined. This study aimed to determine trimester-specific reference intervals for HbA1c levels in non-diabetic pregnant women in China. METHODS: In this cross-sectional study, 5,042 Chinese pregnant women fro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507880/ https://www.ncbi.nlm.nih.gov/pubmed/37726666 http://dx.doi.org/10.1186/s12884-023-05980-0 |
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author | Deng, Yuguo Cheng, Danling Liao, Guilian Tan, Xiaoyu Yang, Jinying |
author_facet | Deng, Yuguo Cheng, Danling Liao, Guilian Tan, Xiaoyu Yang, Jinying |
author_sort | Deng, Yuguo |
collection | PubMed |
description | BACKGROUND: Physiological glycated hemoglobin (HbA1c) values in each trimester are not well defined. This study aimed to determine trimester-specific reference intervals for HbA1c levels in non-diabetic pregnant women in China. METHODS: In this cross-sectional study, 5,042 Chinese pregnant women from 6 to 41 weeks of gestation were screened. An inclusion of 4,134 non-diabetic women was made to determine the reference intervals, they were divided into three trimesters: trimester 1 (T1), 6 weeks to 13 weeks + 6 days, trimester 2 (T2), 14 weeks to 27 weeks + 6 days, and trimester 3 (T3), 28 weeks to 41 weeks + 6 days. A total of 4,134 women (T1 n = 760, T2 n = 1,953, and T3 n = 1,421) provided blood samples which were analyzed for HbA1c concentrations. HbA1c was measured using high-performance liquid chromatography. The median and percentile (2.5th to 97.5th) for the HbA1c reference intervals were calculated for each trimester. RESULTS: In total, 8,732 HbA1c measurements were taken. Reference intervals for HbA1c expressed as median and percentile (2.5th to 97.5th) for each trimester were: T1: 4.7 (4.0–5.5%), T2: 4.5 (3.9–5.3%), and T3: 4.8 (4.1–5.7%) respectively. The HbA1c levels were significantly lower in the second trimester compared to those in the first trimester (p < 0.0001), and higher in the third trimester compared to the second trimester (p < 0.0001). CONCLUSIONS: The reference intervals for HbA1c levels were 3.9–5.7% with upper limits of 5.5% in the first trimester, 5.3% in the second trimester, and 5.7% in the third trimester. These findings highlight the importance of considering trimester-specific reference intervals for HbA1c in non-diabetic pregnant women to promote maternal and fetal health. |
format | Online Article Text |
id | pubmed-10507880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105078802023-09-20 Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population Deng, Yuguo Cheng, Danling Liao, Guilian Tan, Xiaoyu Yang, Jinying BMC Pregnancy Childbirth Research BACKGROUND: Physiological glycated hemoglobin (HbA1c) values in each trimester are not well defined. This study aimed to determine trimester-specific reference intervals for HbA1c levels in non-diabetic pregnant women in China. METHODS: In this cross-sectional study, 5,042 Chinese pregnant women from 6 to 41 weeks of gestation were screened. An inclusion of 4,134 non-diabetic women was made to determine the reference intervals, they were divided into three trimesters: trimester 1 (T1), 6 weeks to 13 weeks + 6 days, trimester 2 (T2), 14 weeks to 27 weeks + 6 days, and trimester 3 (T3), 28 weeks to 41 weeks + 6 days. A total of 4,134 women (T1 n = 760, T2 n = 1,953, and T3 n = 1,421) provided blood samples which were analyzed for HbA1c concentrations. HbA1c was measured using high-performance liquid chromatography. The median and percentile (2.5th to 97.5th) for the HbA1c reference intervals were calculated for each trimester. RESULTS: In total, 8,732 HbA1c measurements were taken. Reference intervals for HbA1c expressed as median and percentile (2.5th to 97.5th) for each trimester were: T1: 4.7 (4.0–5.5%), T2: 4.5 (3.9–5.3%), and T3: 4.8 (4.1–5.7%) respectively. The HbA1c levels were significantly lower in the second trimester compared to those in the first trimester (p < 0.0001), and higher in the third trimester compared to the second trimester (p < 0.0001). CONCLUSIONS: The reference intervals for HbA1c levels were 3.9–5.7% with upper limits of 5.5% in the first trimester, 5.3% in the second trimester, and 5.7% in the third trimester. These findings highlight the importance of considering trimester-specific reference intervals for HbA1c in non-diabetic pregnant women to promote maternal and fetal health. BioMed Central 2023-09-19 /pmc/articles/PMC10507880/ /pubmed/37726666 http://dx.doi.org/10.1186/s12884-023-05980-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Deng, Yuguo Cheng, Danling Liao, Guilian Tan, Xiaoyu Yang, Jinying Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
title | Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
title_full | Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
title_fullStr | Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
title_full_unstemmed | Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
title_short | Trimester-specific reference intervals for hemoglobin A1c in non-diabetic pregnancy in a Chinese population |
title_sort | trimester-specific reference intervals for hemoglobin a1c in non-diabetic pregnancy in a chinese population |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507880/ https://www.ncbi.nlm.nih.gov/pubmed/37726666 http://dx.doi.org/10.1186/s12884-023-05980-0 |
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