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Intrathecal chemotherapy for the management of lymphoblastic lymphoma in a 4-year-old dog: a case report

Intrathecal chemotherapy is used in human medicine for the treatment or prophylaxis of CNS hematopoietic neoplasia. However, the clinical benefits in veterinary medicine have been scarcely documented. A 4-year-old male entire cross-breed dog presented with a 24-h history of severe lethargy, pelvic l...

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Autores principales: Lyseight, Filipa Louise Simões, Dupont, Christophe Osterreicher Cunha, Cherubini, Giunio Bruto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507905/
https://www.ncbi.nlm.nih.gov/pubmed/37732143
http://dx.doi.org/10.3389/fvets.2023.1209935
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author Lyseight, Filipa Louise Simões
Dupont, Christophe Osterreicher Cunha
Cherubini, Giunio Bruto
author_facet Lyseight, Filipa Louise Simões
Dupont, Christophe Osterreicher Cunha
Cherubini, Giunio Bruto
author_sort Lyseight, Filipa Louise Simões
collection PubMed
description Intrathecal chemotherapy is used in human medicine for the treatment or prophylaxis of CNS hematopoietic neoplasia. However, the clinical benefits in veterinary medicine have been scarcely documented. A 4-year-old male entire cross-breed dog presented with a 24-h history of severe lethargy, pelvic limb weakness, and urinary retention. Examination revealed generalized peripheral lymphadenomegaly, and the neurological findings were suggestive of a myelopathy in the region of T3-L3. Following the diagnosis of multicentric lymphoblastic B-cell lymphoma (stage Vb), a modified L-LOP with cytosine arabinoside was started, and complete clinical remission was achieved. After 4 weeks, there was acute neurological deterioration (spinal pain and proprioceptive deficits) without peripheral lymphadenomegaly. MRI findings and CSF analysis were consistent with meningeal and spinal cord lymphoma infiltration at the level of L3. Intrathecal chemotherapy (cytosine arabinoside and methotrexate) were administered in the cisterna magna with systemic dexamethasone and analgesia. Clinical signs were resolved within 24 h, and the patient remained asymptomatic for 3.5 weeks. After this period, CNS relapse (proprioceptive deficits and severe thoracolumbar pain) was suspected, and repeat intrathecal chemotherapy was declined. The patient was humanely euthanized 9 weeks after the initial diagnosis. This is the first report on the clinical benefit of intrathecal chemotherapy with a combination of methotrexate and cytarabine for the management of CNS lymphoma in dogs. Based on our case, intrathecal chemotherapy with methotrexate and cytarabine can induce a short-lasting CNS clinical remission (3 weeks).
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spelling pubmed-105079052023-09-20 Intrathecal chemotherapy for the management of lymphoblastic lymphoma in a 4-year-old dog: a case report Lyseight, Filipa Louise Simões Dupont, Christophe Osterreicher Cunha Cherubini, Giunio Bruto Front Vet Sci Veterinary Science Intrathecal chemotherapy is used in human medicine for the treatment or prophylaxis of CNS hematopoietic neoplasia. However, the clinical benefits in veterinary medicine have been scarcely documented. A 4-year-old male entire cross-breed dog presented with a 24-h history of severe lethargy, pelvic limb weakness, and urinary retention. Examination revealed generalized peripheral lymphadenomegaly, and the neurological findings were suggestive of a myelopathy in the region of T3-L3. Following the diagnosis of multicentric lymphoblastic B-cell lymphoma (stage Vb), a modified L-LOP with cytosine arabinoside was started, and complete clinical remission was achieved. After 4 weeks, there was acute neurological deterioration (spinal pain and proprioceptive deficits) without peripheral lymphadenomegaly. MRI findings and CSF analysis were consistent with meningeal and spinal cord lymphoma infiltration at the level of L3. Intrathecal chemotherapy (cytosine arabinoside and methotrexate) were administered in the cisterna magna with systemic dexamethasone and analgesia. Clinical signs were resolved within 24 h, and the patient remained asymptomatic for 3.5 weeks. After this period, CNS relapse (proprioceptive deficits and severe thoracolumbar pain) was suspected, and repeat intrathecal chemotherapy was declined. The patient was humanely euthanized 9 weeks after the initial diagnosis. This is the first report on the clinical benefit of intrathecal chemotherapy with a combination of methotrexate and cytarabine for the management of CNS lymphoma in dogs. Based on our case, intrathecal chemotherapy with methotrexate and cytarabine can induce a short-lasting CNS clinical remission (3 weeks). Frontiers Media S.A. 2023-09-05 /pmc/articles/PMC10507905/ /pubmed/37732143 http://dx.doi.org/10.3389/fvets.2023.1209935 Text en Copyright © 2023 Lyseight, Dupont and Cherubini. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Lyseight, Filipa Louise Simões
Dupont, Christophe Osterreicher Cunha
Cherubini, Giunio Bruto
Intrathecal chemotherapy for the management of lymphoblastic lymphoma in a 4-year-old dog: a case report
title Intrathecal chemotherapy for the management of lymphoblastic lymphoma in a 4-year-old dog: a case report
title_full Intrathecal chemotherapy for the management of lymphoblastic lymphoma in a 4-year-old dog: a case report
title_fullStr Intrathecal chemotherapy for the management of lymphoblastic lymphoma in a 4-year-old dog: a case report
title_full_unstemmed Intrathecal chemotherapy for the management of lymphoblastic lymphoma in a 4-year-old dog: a case report
title_short Intrathecal chemotherapy for the management of lymphoblastic lymphoma in a 4-year-old dog: a case report
title_sort intrathecal chemotherapy for the management of lymphoblastic lymphoma in a 4-year-old dog: a case report
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507905/
https://www.ncbi.nlm.nih.gov/pubmed/37732143
http://dx.doi.org/10.3389/fvets.2023.1209935
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