Cargando…

Comparison of Huntington’s disease phenotype progression in male and female heterozygous FDNQ175 mice

Huntington’s Disease (HD) is an inherited autosomal dominant neurodegenerative disorder that leads to progressive motor and cognitive impairment due to the expansion of a polyglutamine (CAG) repeat in the N-terminal region of the huntingtin (Htt) protein. The creation of HD mouse models represents a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Si Han, Colson, Tash-Lynn L., Chen, Jingwei, Abd-Elrahman, Khaled S., Ferguson, Stephen S. G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508000/ https://www.ncbi.nlm.nih.gov/pubmed/37726802 http://dx.doi.org/10.1186/s13041-023-01054-6

Ejemplares similares

Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington’s Mice
por: Li, Si Han, et al.
Publicado: (2022)

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
por: Abd-Elrahman, Khaled S., et al.
Publicado: (2019)

Progression of basal ganglia pathology in heterozygous Q175 knock‐in Huntington's disease mice
por: Deng, Yunping, et al.
Publicado: (2020)

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease
por: Cutler, Tamara S., et al.
Publicado: (2017)

mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease
por: de Souza, Jéssica M., et al.
Publicado: (2020)

Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease
por: Sanchis, Ana, et al.
Publicado: (2019)

Small Molecule Pytren-4QMn Metal Complex Slows down Huntington’s Disease Progression in Male zQ175 Transgenic Mice
por: Merino, Marián, et al.
Publicado: (2023)

The Onset and Progression of Hippocampal Synaptic Plasticity Deficits in the Q175FDN Mouse Model of Huntington Disease
por: Quirion, Jade G., et al.
Publicado: (2019)

Global Rhes knockout in the Q175 Huntington’s disease mouse model
por: Heikkinen, Taneli, et al.
Publicado: (2021)

A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington’s disease
por: Oakeshott, Stephen, et al.
Publicado: (2012)

Heterozygous c.175C>T variant in PURA gene causes severe developmental delay
por: Noda, Yusuke, et al.
Publicado: (2023)

Cholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntington’s Disease
por: Tanimura, Asami, et al.
Publicado: (2016)

Abnormal Brain Development in Huntington’ Disease Is Recapitulated in the zQ175 Knock-In Mouse Model
por: Zhang, Chuangchuang, et al.
Publicado: (2020)

Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175(+/−) Mouse Model of Huntington's Disease
por: Lim, Sean Austin O., et al.
Publicado: (2021)

The Urine Metabolome of R6/2 and zQ175DN Huntington’s Disease Mouse Models
por: Speziale, Roberto, et al.
Publicado: (2023)

Phenotypic Characterization of Female Carrier Mice Heterozygous for Tafazzin Deletion
por: Tomczewski, Michelle V., et al.
Publicado: (2023)

Genetic Deletion of Transglutaminase 2 Does Not Rescue the Phenotypic Deficits Observed in R6/2 and zQ175 Mouse Models of Huntington's Disease
por: Menalled, Liliana B., et al.
Publicado: (2014)

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175
por: Menalled, Liliana B., et al.
Publicado: (2012)

Impaired Performance of the Q175 Mouse Model of Huntington’s Disease in the Touch Screen Paired Associates Learning Task
por: Piiponniemi, Tuukka O., et al.
Publicado: (2018)

Studies on the Q175 Knock-in Model of Huntington’s Disease Using Functional Imaging in Awake Mice: Evidence of Olfactory Dysfunction
por: Ferris, Craig F., et al.
Publicado: (2014)

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease
por: Wang, Huei-Bin, et al.
Publicado: (2018)

Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum
por: Iuliano, Maria, et al.
Publicado: (2021)

The Role of Neuroglial Metabotropic Glutamate Receptors in Alzheimer’s Disease
por: Abd-Elrahman, Khaled S., et al.
Publicado: (2023)

Phenotypic variability of hyperandrogenemia in females heterozygous for CYP21A2 mutations
por: Neocleous, Vassos, et al.
Publicado: (2014)

The Q175 Mouse Model of Huntington’s Disease Shows Gene Dosage- and Age-Related Decline in Circadian Rhythms of Activity and Sleep
por: Loh, Dawn H., et al.
Publicado: (2013)

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease
por: Peng, Qi, et al.
Publicado: (2016)

Possible use of a H3R antagonist for the management of nonmotor symptoms in the Q175 mouse model of Huntington's disease
por: Whittaker, Daniel S., et al.
Publicado: (2017)

Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington’s Disease Knock-in Mice
por: Schindler, Franziska, et al.
Publicado: (2021)

Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models
por: Abd-Elrahman, Khaled S., et al.
Publicado: (2018)

Optimising Golgi–Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease
por: Bayram-Weston, Zubeyde, et al.
Publicado: (2016)

Phenotypic Variability in Huntington's Disease
por: Chouksey, Anjali, et al.
Publicado: (2020)

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease
por: Heikkinen, Taneli, et al.
Publicado: (2012)

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study
por: Carty, Nikisha, et al.
Publicado: (2015)

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175(+/-) mouse model of Huntington’s Disease
por: Goodliffe, Joseph W., et al.
Publicado: (2018)

Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington’s disease
por: Adhikari, Mohit H., et al.
Publicado: (2023)

VGLUT3 Ablation Differentially Modulates Glutamate Receptor Densities in Mouse Brain
por: Ibrahim, Karim S., et al.
Publicado: (2022)

175 modelos de carpintería /
por: Rodríguez Hernández, Anselmo
Publicado: (1976)

Subject index for volume 175
Publicado: (1990)

Novel Compound Heterozygous Variants in the LHCGR Gene in a Genetically Male Patient with Female External Genitalia
por: Yan, Mei, et al.
Publicado: (2019)

Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice
por: Hayashi, Shuichi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fsn0mdbtibehrja0l46mkvh6ib