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Nano selenium-doped TiO(2) nanotube arrays on orthopedic implants for suppressing osteosarcoma growth
Osteosarcoma, the most common primary malignant bone tumor, is characterized by malignant cells producing osteoid or immature bone tissue. Most osteosarcoma patients require reconstructive surgery to restore the functional and structural integrity of the injured bone. Metal orthopedic implants are c...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508061/ https://www.ncbi.nlm.nih.gov/pubmed/37731757 http://dx.doi.org/10.3389/fbioe.2023.1252816 |
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author | Hu, Xiaodong Ke, Chunhai Zhong, Jiaqi Chen, Yujiong Dong, Jieyang Hao, Mingming Chen, Qi Ni, Jiahua Peng, Zhaoxiang |
author_facet | Hu, Xiaodong Ke, Chunhai Zhong, Jiaqi Chen, Yujiong Dong, Jieyang Hao, Mingming Chen, Qi Ni, Jiahua Peng, Zhaoxiang |
author_sort | Hu, Xiaodong |
collection | PubMed |
description | Osteosarcoma, the most common primary malignant bone tumor, is characterized by malignant cells producing osteoid or immature bone tissue. Most osteosarcoma patients require reconstructive surgery to restore the functional and structural integrity of the injured bone. Metal orthopedic implants are commonly used to restore the limb integrity in postoperative patients. However, conventional metal implants with a bioinert surface cannot inhibit the growth of any remaining cancer cells, resulting in a higher risk of cancer recurrence. Herein, we fabricate a selenium-doped TiO(2) nanotube array (Se-doped TNA) film to modify the surface of medical pure titanium substrate, and evaluate the anti-tumor effect and biocompatibility of Se-doped TNA film. Moreover, we further explore the anti-tumor potential mechanism of Se-doped TNA film by studying the behaviors of human osteosarcoma cells in vitro. We provide a new pathway for achieving the anti-tumor function of orthopedic implants while keeping the biocompatibility, aiming to suppress the recurrence of osteosarcoma. |
format | Online Article Text |
id | pubmed-10508061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105080612023-09-20 Nano selenium-doped TiO(2) nanotube arrays on orthopedic implants for suppressing osteosarcoma growth Hu, Xiaodong Ke, Chunhai Zhong, Jiaqi Chen, Yujiong Dong, Jieyang Hao, Mingming Chen, Qi Ni, Jiahua Peng, Zhaoxiang Front Bioeng Biotechnol Bioengineering and Biotechnology Osteosarcoma, the most common primary malignant bone tumor, is characterized by malignant cells producing osteoid or immature bone tissue. Most osteosarcoma patients require reconstructive surgery to restore the functional and structural integrity of the injured bone. Metal orthopedic implants are commonly used to restore the limb integrity in postoperative patients. However, conventional metal implants with a bioinert surface cannot inhibit the growth of any remaining cancer cells, resulting in a higher risk of cancer recurrence. Herein, we fabricate a selenium-doped TiO(2) nanotube array (Se-doped TNA) film to modify the surface of medical pure titanium substrate, and evaluate the anti-tumor effect and biocompatibility of Se-doped TNA film. Moreover, we further explore the anti-tumor potential mechanism of Se-doped TNA film by studying the behaviors of human osteosarcoma cells in vitro. We provide a new pathway for achieving the anti-tumor function of orthopedic implants while keeping the biocompatibility, aiming to suppress the recurrence of osteosarcoma. Frontiers Media S.A. 2023-09-05 /pmc/articles/PMC10508061/ /pubmed/37731757 http://dx.doi.org/10.3389/fbioe.2023.1252816 Text en Copyright © 2023 Hu, Ke, Zhong, Chen, Dong, Hao, Chen, Ni and Peng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Hu, Xiaodong Ke, Chunhai Zhong, Jiaqi Chen, Yujiong Dong, Jieyang Hao, Mingming Chen, Qi Ni, Jiahua Peng, Zhaoxiang Nano selenium-doped TiO(2) nanotube arrays on orthopedic implants for suppressing osteosarcoma growth |
title | Nano selenium-doped TiO(2) nanotube arrays on orthopedic implants for suppressing osteosarcoma growth |
title_full | Nano selenium-doped TiO(2) nanotube arrays on orthopedic implants for suppressing osteosarcoma growth |
title_fullStr | Nano selenium-doped TiO(2) nanotube arrays on orthopedic implants for suppressing osteosarcoma growth |
title_full_unstemmed | Nano selenium-doped TiO(2) nanotube arrays on orthopedic implants for suppressing osteosarcoma growth |
title_short | Nano selenium-doped TiO(2) nanotube arrays on orthopedic implants for suppressing osteosarcoma growth |
title_sort | nano selenium-doped tio(2) nanotube arrays on orthopedic implants for suppressing osteosarcoma growth |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508061/ https://www.ncbi.nlm.nih.gov/pubmed/37731757 http://dx.doi.org/10.3389/fbioe.2023.1252816 |
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