New boronate drugs and evolving NDM-mediated beta-lactam resistance

Taniborbactam and xeruborbactam are dual serine-/metallo-beta-lactamase inhibitors (BLIs) based on a cyclic boronic acid pharmacophore that undergo clinical development. Recent report demonstrated that New Delhi metallo-beta-lactamase (NDM)-9 (differs from NDM-1 by a single amino acid substitution,...

Descripción completa

Detalles Bibliográficos
Autores principales: Lomovskaya, Olga, Tsivkovski, Ruslan, Totrov, Maxim, Dressel, Dana, Castanheira, Mariana, Dudley, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508144/
https://www.ncbi.nlm.nih.gov/pubmed/37650617
http://dx.doi.org/10.1128/aac.00579-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508144/
https://www.ncbi.nlm.nih.gov/pubmed/37650617
http://dx.doi.org/10.1128/aac.00579-23

Ejemplares similares