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New boronate drugs and evolving NDM-mediated beta-lactam resistance

Taniborbactam and xeruborbactam are dual serine-/metallo-beta-lactamase inhibitors (BLIs) based on a cyclic boronic acid pharmacophore that undergo clinical development. Recent report demonstrated that New Delhi metallo-beta-lactamase (NDM)-9 (differs from NDM-1 by a single amino acid substitution,...

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Detalles Bibliográficos
Autores principales:	Lomovskaya, Olga, Tsivkovski, Ruslan, Totrov, Maxim, Dressel, Dana, Castanheira, Mariana, Dudley, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508144/ https://www.ncbi.nlm.nih.gov/pubmed/37650617 http://dx.doi.org/10.1128/aac.00579-23

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