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AKR1C3 Converts Castrate and Post-Abiraterone DHEA-S into Testosterone to Stimulate Growth of Prostate Cancer Cells via 5-Androstene-3β,17β-Diol

Androgen receptor signaling inhibitors (ARSI) are used to treat castration-resistant prostate cancer (CRPC) to stop a resurgence of androgen receptor (AR) signaling. Despite early success, patients on ARSIs eventually relapse, develop drug resistance, and succumb to the disease. Resistance may occur...

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Detalles Bibliográficos
Autores principales:	Detlefsen, Andrea J., Mesaros, Clementina A., Duan, Ling, Penning, Trevor M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508215/ https://www.ncbi.nlm.nih.gov/pubmed/37772993 http://dx.doi.org/10.1158/2767-9764.CRC-23-0235

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