Synthesis, biological evaluation and computer-aided discovery of new thiazolidine-2,4-dione derivatives as potential antitumor VEGFR-2 inhibitors

In this study, novel VEGFR-2-targeting thiazolidine-2,4-dione derivatives with potential anticancer properties were designed and synthesized. The ability of the designed derivatives to inhibit VEGFR-2 and stop the growth of three different cancer cell types (HT-29, A-549, and HCT-116) was examined i...

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Detalles Bibliográficos
Autores principales: Elkady, Hazem, El-Dardir, Osama A., Elwan, Alaa, Taghour, Mohammed S., Mahdy, Hazem A., Dahab, Mohammed A., Elkaeed, Eslam B., Alsfouk, Bshra A., Ibrahim, Ibrahim M., Husein, Dalal Z., Hafez, Elsayed E., Darwish, Amira M. G., Metwaly, Ahmed M., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508263/
https://www.ncbi.nlm.nih.gov/pubmed/37731835
http://dx.doi.org/10.1039/d3ra05689a

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