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Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles

INTRODUCTION: Topical application of capsaicin can produce an ongoing pain state in healthy participants. However, approximately one-third report no pain response (ie, nonresponders), and the reasons for this are poorly understood. OBJECTIVES: In this study, we investigated temporal summation of pai...

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Autores principales: Wong, Felyx, Reddy, Aditi, Rho, Yeanuk, Vollert, Jan, Strutton, Paul H., Hughes, Sam W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508395/
https://www.ncbi.nlm.nih.gov/pubmed/37731476
http://dx.doi.org/10.1097/PR9.0000000000001071
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author Wong, Felyx
Reddy, Aditi
Rho, Yeanuk
Vollert, Jan
Strutton, Paul H.
Hughes, Sam W.
author_facet Wong, Felyx
Reddy, Aditi
Rho, Yeanuk
Vollert, Jan
Strutton, Paul H.
Hughes, Sam W.
author_sort Wong, Felyx
collection PubMed
description INTRODUCTION: Topical application of capsaicin can produce an ongoing pain state in healthy participants. However, approximately one-third report no pain response (ie, nonresponders), and the reasons for this are poorly understood. OBJECTIVES: In this study, we investigated temporal summation of pain (TSP) profiles, pain ratings and secondary hyperalgesia responses in responders and nonresponders to 1% topical capsaicin cream. METHODS: Assessments were made at baseline and then during an early (ie, 15 minutes) and late (ie, 45 minutes) time points post-capsaicin in 37 healthy participants. RESULTS: Participants reporting a visual analogue scale (VAS) rating of >50 were defined as responders (n = 24) and those with <50 VAS rating were defined as nonresponders (n = 13). There was a facilitation of TSP during the transition from an early to the late time point post-capsaicin (P<0.001) and the development of secondary hyperalgesia (P<0.05) in the responder group. Nonresponders showed no changes in TSP or secondary hyperalgesia during the early and late time points. There was an association between baseline TSP scores and the later development of a responder or nonresponder phenotype (r = 0.36; P = 0.03). Receiver operating characteristic analysis revealed that baseline TSP works as a good response predictor at an individual level (area under the curve = 0.75). CONCLUSION: These data suggest that responders and nonresponders have different facilitatory pain mechanisms. The assessment of TSP may help to identify participants with stronger endogenous pain facilitation who may be more likely to respond to topical capsaicin.
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spelling pubmed-105083952023-09-20 Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles Wong, Felyx Reddy, Aditi Rho, Yeanuk Vollert, Jan Strutton, Paul H. Hughes, Sam W. Pain Rep General Section INTRODUCTION: Topical application of capsaicin can produce an ongoing pain state in healthy participants. However, approximately one-third report no pain response (ie, nonresponders), and the reasons for this are poorly understood. OBJECTIVES: In this study, we investigated temporal summation of pain (TSP) profiles, pain ratings and secondary hyperalgesia responses in responders and nonresponders to 1% topical capsaicin cream. METHODS: Assessments were made at baseline and then during an early (ie, 15 minutes) and late (ie, 45 minutes) time points post-capsaicin in 37 healthy participants. RESULTS: Participants reporting a visual analogue scale (VAS) rating of >50 were defined as responders (n = 24) and those with <50 VAS rating were defined as nonresponders (n = 13). There was a facilitation of TSP during the transition from an early to the late time point post-capsaicin (P<0.001) and the development of secondary hyperalgesia (P<0.05) in the responder group. Nonresponders showed no changes in TSP or secondary hyperalgesia during the early and late time points. There was an association between baseline TSP scores and the later development of a responder or nonresponder phenotype (r = 0.36; P = 0.03). Receiver operating characteristic analysis revealed that baseline TSP works as a good response predictor at an individual level (area under the curve = 0.75). CONCLUSION: These data suggest that responders and nonresponders have different facilitatory pain mechanisms. The assessment of TSP may help to identify participants with stronger endogenous pain facilitation who may be more likely to respond to topical capsaicin. Wolters Kluwer 2023-04-04 /pmc/articles/PMC10508395/ /pubmed/37731476 http://dx.doi.org/10.1097/PR9.0000000000001071 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle General Section
Wong, Felyx
Reddy, Aditi
Rho, Yeanuk
Vollert, Jan
Strutton, Paul H.
Hughes, Sam W.
Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles
title Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles
title_full Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles
title_fullStr Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles
title_full_unstemmed Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles
title_short Responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles
title_sort responders and nonresponders to topical capsaicin display distinct temporal summation of pain profiles
topic General Section
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508395/
https://www.ncbi.nlm.nih.gov/pubmed/37731476
http://dx.doi.org/10.1097/PR9.0000000000001071
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