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Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity
Chorangiocarcinoma is an extremely rare tumor seen in the placenta, with only six cases reported in the literature so far. Its morphological characteristics, criteria for diagnosis, and the pathophysiology remain controversial to date. Although it was predominantly considered a benign entity, a soli...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Federation of Turkish Pathology Societies
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508416/ https://www.ncbi.nlm.nih.gov/pubmed/34514581 http://dx.doi.org/10.5146/tjpath.2021.01548 |
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author | Sagar, Nishant Tanwar, Parul Khurana, Nita Kashyap, Poonam |
author_facet | Sagar, Nishant Tanwar, Parul Khurana, Nita Kashyap, Poonam |
author_sort | Sagar, Nishant |
collection | PubMed |
description | Chorangiocarcinoma is an extremely rare tumor seen in the placenta, with only six cases reported in the literature so far. Its morphological characteristics, criteria for diagnosis, and the pathophysiology remain controversial to date. Although it was predominantly considered a benign entity, a solitary case of distant metastasis has been reported in the literature. We present a case of this unusual tumor in the preterm placenta of a 29-year-old female. Grossly seen as a grey white nodule, microscopic examination revealed nests of atypical trophoblastic proliferation surrounded by vascularized stroma. No evidence of basement membrane invasion was noted. On immunohistochemistry, the trophoblastic component expressed pancytokeratin, Beta HCG, and Placental Alkaline Phosphatase with high Ki-67 labelling index. The present case highlights this exceedingly rare entity with emphasis on its morpho-immunohistochemical features along with a review of literature. |
format | Online Article Text |
id | pubmed-10508416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Federation of Turkish Pathology Societies |
record_format | MEDLINE/PubMed |
spelling | pubmed-105084162023-09-20 Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity Sagar, Nishant Tanwar, Parul Khurana, Nita Kashyap, Poonam Turk Patoloji Derg Case Report Chorangiocarcinoma is an extremely rare tumor seen in the placenta, with only six cases reported in the literature so far. Its morphological characteristics, criteria for diagnosis, and the pathophysiology remain controversial to date. Although it was predominantly considered a benign entity, a solitary case of distant metastasis has been reported in the literature. We present a case of this unusual tumor in the preterm placenta of a 29-year-old female. Grossly seen as a grey white nodule, microscopic examination revealed nests of atypical trophoblastic proliferation surrounded by vascularized stroma. No evidence of basement membrane invasion was noted. On immunohistochemistry, the trophoblastic component expressed pancytokeratin, Beta HCG, and Placental Alkaline Phosphatase with high Ki-67 labelling index. The present case highlights this exceedingly rare entity with emphasis on its morpho-immunohistochemical features along with a review of literature. Federation of Turkish Pathology Societies 2022-09-15 /pmc/articles/PMC10508416/ /pubmed/34514581 http://dx.doi.org/10.5146/tjpath.2021.01548 Text en Copyright © 2022 The Author(s). https://creativecommons.org/licenses/by/4.0/This is an open-access article published by Federation of Turkish Pathology Societies under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Case Report Sagar, Nishant Tanwar, Parul Khurana, Nita Kashyap, Poonam Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity |
title | Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity |
title_full | Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity |
title_fullStr | Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity |
title_full_unstemmed | Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity |
title_short | Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity |
title_sort | placental chorangiocarcinoma: case report with literature review of a rare entity |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508416/ https://www.ncbi.nlm.nih.gov/pubmed/34514581 http://dx.doi.org/10.5146/tjpath.2021.01548 |
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