Cargando…

Clinicopathological correlations of endometrioid and clear cell carcinomas in the uterus and ovary

Endometrioid carcinoma (EC) and clear cell carcinoma (CC) are associated with endometrial tissue hyperplasia and endometriosis, and they occur in the endometrium and ovaries. However, detailed differences between these tumors based on immunostaining are unclear; therefore, in this study, we aimed to...

Descripción completa

Detalles Bibliográficos
Autores principales: Mori, Hidemi, Nishida, Haruto, Kusaba, Takahiro, Kawamura, Kazuhiro, Oyama, Yuzo, Daa, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508447/
https://www.ncbi.nlm.nih.gov/pubmed/37713813
http://dx.doi.org/10.1097/MD.0000000000035301
_version_ 1785107537769529344
author Mori, Hidemi
Nishida, Haruto
Kusaba, Takahiro
Kawamura, Kazuhiro
Oyama, Yuzo
Daa, Tsutomu
author_facet Mori, Hidemi
Nishida, Haruto
Kusaba, Takahiro
Kawamura, Kazuhiro
Oyama, Yuzo
Daa, Tsutomu
author_sort Mori, Hidemi
collection PubMed
description Endometrioid carcinoma (EC) and clear cell carcinoma (CC) are associated with endometrial tissue hyperplasia and endometriosis, and they occur in the endometrium and ovaries. However, detailed differences between these tumors based on immunostaining are unclear; therefore, in this study, we aimed to analyze the clinicopathological correlations between these tumors using immunostaining and to develop new treatments based on histological subtypes. Immunohistochemistry was used to investigate differentially expressed hypoxia-associated molecules (hypoxia-inducible factor-1 subunit alpha [HIF-1α], forkhead box O1, prostate-specific membrane antigen, signal transducer and activator of transcription 3 [STAT3], hepatocyte nuclear factor 1β [HNF-1β], aquaporin-3, and vimentin [VIM]) between these carcinomas because of the reported association between CC and ischemia. Immunostaining and clinicopathological data from 70 patients (21 uterine endometrioid carcinomas [UECs], 9 uterine cell carcinomas, 20 ovarian endometrioid carcinomas [OECs], and 20 ovarian cell carcinomas [OCCs]) were compared. HIF-1α and prostate-specific membrane antigen expression levels were higher in UEC and OCC than in uterine cell carcinomas and OEC. STAT3 was slightly overexpressed in UEC. Additionally, forkhead box O1 expression was either absent or significantly attenuated in all ECs. VIM and AQ3 were highly expressed in UEC, whereas HNF-1β expression was higher in OCC. UEC, OEC, and OCC were more common in the uterine fundus, left ovary, and right ovary, respectively. Ovarian endometriosis was strongly associated with EC. Our findings suggest that UEC and OCC share a carcinogenic pathway that involves HIF-1α induction under hypoxic conditions via STAT3 expression, resulting in angiogenesis. Furthermore, the anatomical position of carcinomas may contribute to their carcinogenesis. Finally, aquaporin-3 and VIM demonstrate strong potential as biomarkers for UEC, whereas HNF-1β expression is a crucial factor in CC development. These differences in tumor site and histological subtypes shown in this study will lead to the establishment of treatment based on histological and immunohistological classification.
format Online
Article
Text
id pubmed-10508447
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-105084472023-09-20 Clinicopathological correlations of endometrioid and clear cell carcinomas in the uterus and ovary Mori, Hidemi Nishida, Haruto Kusaba, Takahiro Kawamura, Kazuhiro Oyama, Yuzo Daa, Tsutomu Medicine (Baltimore) Research Article: Observational Study Endometrioid carcinoma (EC) and clear cell carcinoma (CC) are associated with endometrial tissue hyperplasia and endometriosis, and they occur in the endometrium and ovaries. However, detailed differences between these tumors based on immunostaining are unclear; therefore, in this study, we aimed to analyze the clinicopathological correlations between these tumors using immunostaining and to develop new treatments based on histological subtypes. Immunohistochemistry was used to investigate differentially expressed hypoxia-associated molecules (hypoxia-inducible factor-1 subunit alpha [HIF-1α], forkhead box O1, prostate-specific membrane antigen, signal transducer and activator of transcription 3 [STAT3], hepatocyte nuclear factor 1β [HNF-1β], aquaporin-3, and vimentin [VIM]) between these carcinomas because of the reported association between CC and ischemia. Immunostaining and clinicopathological data from 70 patients (21 uterine endometrioid carcinomas [UECs], 9 uterine cell carcinomas, 20 ovarian endometrioid carcinomas [OECs], and 20 ovarian cell carcinomas [OCCs]) were compared. HIF-1α and prostate-specific membrane antigen expression levels were higher in UEC and OCC than in uterine cell carcinomas and OEC. STAT3 was slightly overexpressed in UEC. Additionally, forkhead box O1 expression was either absent or significantly attenuated in all ECs. VIM and AQ3 were highly expressed in UEC, whereas HNF-1β expression was higher in OCC. UEC, OEC, and OCC were more common in the uterine fundus, left ovary, and right ovary, respectively. Ovarian endometriosis was strongly associated with EC. Our findings suggest that UEC and OCC share a carcinogenic pathway that involves HIF-1α induction under hypoxic conditions via STAT3 expression, resulting in angiogenesis. Furthermore, the anatomical position of carcinomas may contribute to their carcinogenesis. Finally, aquaporin-3 and VIM demonstrate strong potential as biomarkers for UEC, whereas HNF-1β expression is a crucial factor in CC development. These differences in tumor site and histological subtypes shown in this study will lead to the establishment of treatment based on histological and immunohistological classification. Lippincott Williams & Wilkins 2023-09-15 /pmc/articles/PMC10508447/ /pubmed/37713813 http://dx.doi.org/10.1097/MD.0000000000035301 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article: Observational Study
Mori, Hidemi
Nishida, Haruto
Kusaba, Takahiro
Kawamura, Kazuhiro
Oyama, Yuzo
Daa, Tsutomu
Clinicopathological correlations of endometrioid and clear cell carcinomas in the uterus and ovary
title Clinicopathological correlations of endometrioid and clear cell carcinomas in the uterus and ovary
title_full Clinicopathological correlations of endometrioid and clear cell carcinomas in the uterus and ovary
title_fullStr Clinicopathological correlations of endometrioid and clear cell carcinomas in the uterus and ovary
title_full_unstemmed Clinicopathological correlations of endometrioid and clear cell carcinomas in the uterus and ovary
title_short Clinicopathological correlations of endometrioid and clear cell carcinomas in the uterus and ovary
title_sort clinicopathological correlations of endometrioid and clear cell carcinomas in the uterus and ovary
topic Research Article: Observational Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508447/
https://www.ncbi.nlm.nih.gov/pubmed/37713813
http://dx.doi.org/10.1097/MD.0000000000035301
work_keys_str_mv AT morihidemi clinicopathologicalcorrelationsofendometrioidandclearcellcarcinomasintheuterusandovary
AT nishidaharuto clinicopathologicalcorrelationsofendometrioidandclearcellcarcinomasintheuterusandovary
AT kusabatakahiro clinicopathologicalcorrelationsofendometrioidandclearcellcarcinomasintheuterusandovary
AT kawamurakazuhiro clinicopathologicalcorrelationsofendometrioidandclearcellcarcinomasintheuterusandovary
AT oyamayuzo clinicopathologicalcorrelationsofendometrioidandclearcellcarcinomasintheuterusandovary
AT daatsutomu clinicopathologicalcorrelationsofendometrioidandclearcellcarcinomasintheuterusandovary