Preclinical study in a postoperative pain model to investigate the action of ketamine, lidocaine, and ascorbic acid in reversing fentanyl-induced, non–glutamate-dependent hyperalgesia

INTRODUCTION: Opioid-induced hyperalgesia (OIH) is a paradoxical phenomenon in which exposure to opioids can increase sensitivity to painful stimuli. Currently, several drugs have been used in an attempt to prevent OIH. We design this study to address the effect of preemptive treatment with ketamine...

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Detalles Bibliográficos
Autores principales: Delgado, Marina Ayres, Ferreira, Luana Assis, Gomes, Bianka Jaciara dos Santos, Leite, Isis Katarine Orlandi, Gomez, Marcus Vinícius, Castro-Junior, Célio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508464/
https://www.ncbi.nlm.nih.gov/pubmed/37731750
http://dx.doi.org/10.1097/PR9.0000000000001062

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