Development of a population pharmacokinetic model to characterize the pharmacokinetics of intrathecally administered tominersen in cerebrospinal fluid and plasma

Tominersen is an intrathecally administered antisense oligonucleotide targeting huntingtin mRNA which leads to a dose‐dependent, reversible lowering of cerebrospinal fluid (CSF) mutant huntingtin protein concentration in individuals with Huntington's disease. Nonlinear mixed‐effect population p...

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Detalles Bibliográficos
Autores principales: Yamamoto, Yumi, Sanwald Ducray, Patricia, Björnsson, Marcus, Smart, Kevin, Grimsey, Paul, Vatakuti, Suresh, Portron, Agnes, Massonnet, Benoit, Norris, Daniel A., Silber Baumann, Hanna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508503/
https://www.ncbi.nlm.nih.gov/pubmed/37221972
http://dx.doi.org/10.1002/psp4.13001

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