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Serum uric acid and triglycerides in clear cell renal cell carcinoma: A restrospective cross-sectional study

The available evidence on the relationship between serum uric acid and triglycerides in clear cell renal cell carcinoma (ccRCC) is limited. The objective of this study is to investigate whether there is an independent association between serum uric acid and triglycerides in ccRCC, while adjusting fo...

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Autores principales: Yue, Dong, Tian, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508505/
https://www.ncbi.nlm.nih.gov/pubmed/37713861
http://dx.doi.org/10.1097/MD.0000000000034645
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author Yue, Dong
Tian, Jun
author_facet Yue, Dong
Tian, Jun
author_sort Yue, Dong
collection PubMed
description The available evidence on the relationship between serum uric acid and triglycerides in clear cell renal cell carcinoma (ccRCC) is limited. The objective of this study is to investigate whether there is an independent association between serum uric acid and triglycerides in ccRCC, while adjusting for other variables. This cross-sectional study involved 1018 participants with ccRCC, who were admitted to a hospital in China from December 1st, 2013 to January 1st, 2023. The main independent variable investigated was serum uric acid, which was measured at baseline. The dependent variable was triglycerides. Covariates considered in this study included age, sex, body mass index, smoking status, hypertension, diabetes, coronary disease, High-density lipoprotein cholesterol, Low-density lipoprotein cholesterol, Total cholesterol, Blood urea nitrogen, and Creatinine. The study included 1018 participants with an average age of 56.92 ± 10.88 years old, and approximately 68% of them were male. The fully-adjusted linear regression analysis indicated a positive association between serum uric acid levels (100μmol/L) and triglyceride levels (mmol/L) after adjusting for confounding factors (β = 0.13, 95% CI [0.07, 0.18]). Furthermore, a smooth curve was constructed between serum uric acid and triglycerides based on the fully-adjusted model. In patients with ccRCC, there was a positive association between serum uric acid and triglycerides.
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spelling pubmed-105085052023-09-20 Serum uric acid and triglycerides in clear cell renal cell carcinoma: A restrospective cross-sectional study Yue, Dong Tian, Jun Medicine (Baltimore) 7300 The available evidence on the relationship between serum uric acid and triglycerides in clear cell renal cell carcinoma (ccRCC) is limited. The objective of this study is to investigate whether there is an independent association between serum uric acid and triglycerides in ccRCC, while adjusting for other variables. This cross-sectional study involved 1018 participants with ccRCC, who were admitted to a hospital in China from December 1st, 2013 to January 1st, 2023. The main independent variable investigated was serum uric acid, which was measured at baseline. The dependent variable was triglycerides. Covariates considered in this study included age, sex, body mass index, smoking status, hypertension, diabetes, coronary disease, High-density lipoprotein cholesterol, Low-density lipoprotein cholesterol, Total cholesterol, Blood urea nitrogen, and Creatinine. The study included 1018 participants with an average age of 56.92 ± 10.88 years old, and approximately 68% of them were male. The fully-adjusted linear regression analysis indicated a positive association between serum uric acid levels (100μmol/L) and triglyceride levels (mmol/L) after adjusting for confounding factors (β = 0.13, 95% CI [0.07, 0.18]). Furthermore, a smooth curve was constructed between serum uric acid and triglycerides based on the fully-adjusted model. In patients with ccRCC, there was a positive association between serum uric acid and triglycerides. Lippincott Williams & Wilkins 2023-09-15 /pmc/articles/PMC10508505/ /pubmed/37713861 http://dx.doi.org/10.1097/MD.0000000000034645 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 7300
Yue, Dong
Tian, Jun
Serum uric acid and triglycerides in clear cell renal cell carcinoma: A restrospective cross-sectional study
title Serum uric acid and triglycerides in clear cell renal cell carcinoma: A restrospective cross-sectional study
title_full Serum uric acid and triglycerides in clear cell renal cell carcinoma: A restrospective cross-sectional study
title_fullStr Serum uric acid and triglycerides in clear cell renal cell carcinoma: A restrospective cross-sectional study
title_full_unstemmed Serum uric acid and triglycerides in clear cell renal cell carcinoma: A restrospective cross-sectional study
title_short Serum uric acid and triglycerides in clear cell renal cell carcinoma: A restrospective cross-sectional study
title_sort serum uric acid and triglycerides in clear cell renal cell carcinoma: a restrospective cross-sectional study
topic 7300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508505/
https://www.ncbi.nlm.nih.gov/pubmed/37713861
http://dx.doi.org/10.1097/MD.0000000000034645
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