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Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis
This study evaluated the effects of antibiotics on the implantation rate (IR) as well as the optimal time interval from endometrial biopsy to subsequent embryo transfer (ET) to explore proper chronic endometritis (CE) management. We retrospectively analyzed the clinical data of patients who had fail...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508538/ https://www.ncbi.nlm.nih.gov/pubmed/37713900 http://dx.doi.org/10.1097/MD.0000000000034650 |
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author | Yinglan, Zhang Li, Xue Su, Hui |
author_facet | Yinglan, Zhang Li, Xue Su, Hui |
author_sort | Yinglan, Zhang |
collection | PubMed |
description | This study evaluated the effects of antibiotics on the implantation rate (IR) as well as the optimal time interval from endometrial biopsy to subsequent embryo transfer (ET) to explore proper chronic endometritis (CE) management. We retrospectively analyzed the clinical data of patients who had failed 1 or 2 ET cycles and underwent hysteroscopy. CE was diagnosed when 3 or more cluster of differentiation138 - positive plasma cells were found per high-power field. We divided the patients into 3 groups: those with CE who received antibiotics (group 1), those with CE who did not receive antibiotics (group 2), and those without CE (group 3). We found that IR was significantly higher in Group 1 than in Group 2. Furthermore, while the IR in Groups 1 and 3 was significantly higher when the time interval was < 6 months than when the time interval was > 6 months, there were no significant differences in the IR when the time interval was < 2 months or ≥ 2 months but < 6 months. Postbiopsy oral antibiotic therapy significantly improved IR in patients with CE, whereas increasing the time interval from biopsy to ET reduced IR. This study may help to find a higher potential for success in the medical management of patients with CE. |
format | Online Article Text |
id | pubmed-10508538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-105085382023-09-20 Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis Yinglan, Zhang Li, Xue Su, Hui Medicine (Baltimore) 5600 This study evaluated the effects of antibiotics on the implantation rate (IR) as well as the optimal time interval from endometrial biopsy to subsequent embryo transfer (ET) to explore proper chronic endometritis (CE) management. We retrospectively analyzed the clinical data of patients who had failed 1 or 2 ET cycles and underwent hysteroscopy. CE was diagnosed when 3 or more cluster of differentiation138 - positive plasma cells were found per high-power field. We divided the patients into 3 groups: those with CE who received antibiotics (group 1), those with CE who did not receive antibiotics (group 2), and those without CE (group 3). We found that IR was significantly higher in Group 1 than in Group 2. Furthermore, while the IR in Groups 1 and 3 was significantly higher when the time interval was < 6 months than when the time interval was > 6 months, there were no significant differences in the IR when the time interval was < 2 months or ≥ 2 months but < 6 months. Postbiopsy oral antibiotic therapy significantly improved IR in patients with CE, whereas increasing the time interval from biopsy to ET reduced IR. This study may help to find a higher potential for success in the medical management of patients with CE. Lippincott Williams & Wilkins 2023-09-15 /pmc/articles/PMC10508538/ /pubmed/37713900 http://dx.doi.org/10.1097/MD.0000000000034650 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 5600 Yinglan, Zhang Li, Xue Su, Hui Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis |
title | Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis |
title_full | Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis |
title_fullStr | Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis |
title_full_unstemmed | Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis |
title_short | Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis |
title_sort | benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis |
topic | 5600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508538/ https://www.ncbi.nlm.nih.gov/pubmed/37713900 http://dx.doi.org/10.1097/MD.0000000000034650 |
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