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Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis

This study evaluated the effects of antibiotics on the implantation rate (IR) as well as the optimal time interval from endometrial biopsy to subsequent embryo transfer (ET) to explore proper chronic endometritis (CE) management. We retrospectively analyzed the clinical data of patients who had fail...

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Detalles Bibliográficos
Autores principales: Yinglan, Zhang, Li, Xue, Su, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508538/
https://www.ncbi.nlm.nih.gov/pubmed/37713900
http://dx.doi.org/10.1097/MD.0000000000034650
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author Yinglan, Zhang
Li, Xue
Su, Hui
author_facet Yinglan, Zhang
Li, Xue
Su, Hui
author_sort Yinglan, Zhang
collection PubMed
description This study evaluated the effects of antibiotics on the implantation rate (IR) as well as the optimal time interval from endometrial biopsy to subsequent embryo transfer (ET) to explore proper chronic endometritis (CE) management. We retrospectively analyzed the clinical data of patients who had failed 1 or 2 ET cycles and underwent hysteroscopy. CE was diagnosed when 3 or more cluster of differentiation138 - positive plasma cells were found per high-power field. We divided the patients into 3 groups: those with CE who received antibiotics (group 1), those with CE who did not receive antibiotics (group 2), and those without CE (group 3). We found that IR was significantly higher in Group 1 than in Group 2. Furthermore, while the IR in Groups 1 and 3 was significantly higher when the time interval was < 6 months than when the time interval was > 6 months, there were no significant differences in the IR when the time interval was < 2 months or ≥ 2 months but < 6 months. Postbiopsy oral antibiotic therapy significantly improved IR in patients with CE, whereas increasing the time interval from biopsy to ET reduced IR. This study may help to find a higher potential for success in the medical management of patients with CE.
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spelling pubmed-105085382023-09-20 Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis Yinglan, Zhang Li, Xue Su, Hui Medicine (Baltimore) 5600 This study evaluated the effects of antibiotics on the implantation rate (IR) as well as the optimal time interval from endometrial biopsy to subsequent embryo transfer (ET) to explore proper chronic endometritis (CE) management. We retrospectively analyzed the clinical data of patients who had failed 1 or 2 ET cycles and underwent hysteroscopy. CE was diagnosed when 3 or more cluster of differentiation138 - positive plasma cells were found per high-power field. We divided the patients into 3 groups: those with CE who received antibiotics (group 1), those with CE who did not receive antibiotics (group 2), and those without CE (group 3). We found that IR was significantly higher in Group 1 than in Group 2. Furthermore, while the IR in Groups 1 and 3 was significantly higher when the time interval was < 6 months than when the time interval was > 6 months, there were no significant differences in the IR when the time interval was < 2 months or ≥ 2 months but < 6 months. Postbiopsy oral antibiotic therapy significantly improved IR in patients with CE, whereas increasing the time interval from biopsy to ET reduced IR. This study may help to find a higher potential for success in the medical management of patients with CE. Lippincott Williams & Wilkins 2023-09-15 /pmc/articles/PMC10508538/ /pubmed/37713900 http://dx.doi.org/10.1097/MD.0000000000034650 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5600
Yinglan, Zhang
Li, Xue
Su, Hui
Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis
title Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis
title_full Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis
title_fullStr Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis
title_full_unstemmed Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis
title_short Benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis
title_sort benefits of antibiotics and the optimal time interval between biopsy and the next embryo transfer in patients with chronic endometritis
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508538/
https://www.ncbi.nlm.nih.gov/pubmed/37713900
http://dx.doi.org/10.1097/MD.0000000000034650
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