Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks

Many therapies in clinical trials are based on single drug-single target relationships. To further extend this concept to multi-target approaches using multi-targeted drugs, we developed a machine learning pipeline to unravel the target landscape of kinase inhibitors. This pipeline, which we call 3D...

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Detalles Bibliográficos
Autores principales: Kanev, Georgi K., Zhang, Yaran, Kooistra, Albert J., Bender, Andreas, Leurs, Rob, Bailey, David, Würdinger, Thomas, de Graaf, Chris, de Esch, Iwan J. P., Westerman, Bart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508635/
https://www.ncbi.nlm.nih.gov/pubmed/37669273
http://dx.doi.org/10.1371/journal.pcbi.1011301

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