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The simplicity of protein sequence-function relationships
How complicated is the relationship between a protein’s sequence and its function? High-order epistatic interactions among residues are thought to be pervasive, making a protein’s function difficult to predict or understand from its sequence. Most prior studies, however, used methods that misinterpr...
Autores principales: | Park, Yeonwoo, Metzger, Brian P.H., Thornton, Joseph W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508729/ https://www.ncbi.nlm.nih.gov/pubmed/37732229 http://dx.doi.org/10.1101/2023.09.02.556057 |
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