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The simplicity of protein sequence-function relationships

How complicated is the relationship between a protein’s sequence and its function? High-order epistatic interactions among residues are thought to be pervasive, making a protein’s function difficult to predict or understand from its sequence. Most prior studies, however, used methods that misinterpr...

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Detalles Bibliográficos
Autores principales: Park, Yeonwoo, Metzger, Brian P.H., Thornton, Joseph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508729/
https://www.ncbi.nlm.nih.gov/pubmed/37732229
http://dx.doi.org/10.1101/2023.09.02.556057

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