Cargando…

The structure of a C. neoformans polysaccharide motif recognized by protective antibodies: A combined NMR and MD study

Cryptococcus neoformans is a fungal pathogen responsible for cryptococcosis and cryptococcal meningitis. The C. neoformans capsular polysaccharide and shed exopolysaccharide functions both as a key virulence factor and to protect the fungal cell from phagocytosis. Currently, a glycoconjugate of thes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hargett, Audra A., Azurmendi, Hugo F., Crawford, Conor J., Wear, Maggie P., Oscarson, Stefan, Casadevall, Arturo, Freedberg, Darόn I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508755/ https://www.ncbi.nlm.nih.gov/pubmed/37732210 http://dx.doi.org/10.1101/2023.09.06.556507

Ejemplares similares

A synthetic glycan array containing Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide fragments allows the mapping of protective epitopes
por: Guazzelli, Lorenzo, et al.
Publicado: (2020)

Lyophilization induces physicochemical alterations in cryptococcal exopolysaccharide
por: Wear, Maggie P., et al.
Publicado: (2022)

The capsule of Cryptococcus neoformans
por: Casadevall, Arturo, et al.
Publicado: (2018)

Cryptococcus neoformans capsule regrowth experiments reveal dynamics of enlargement and architecture
por: Wear, Maggie P., et al.
Publicado: (2022)

Cryptococcus neoformans Capsular GXM Conformation and Epitope Presentation: A Molecular Modelling Study
por: Kuttel, Michelle M., et al.
Publicado: (2020)

Variation in Cell Surface Hydrophobicity among Cryptococcus neoformans Strains Influences Interactions with Amoebas
por: Vij, Raghav, et al.
Publicado: (2020)

Glycosylation States on Intact Proteins Determined by NMR Spectroscopy
por: Hargett, Audra A., et al.
Publicado: (2021)

Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans
por: Wang, Yina, et al.
Publicado: (2021)

Synthesis of a Glucuronic Acid‐Containing Thioglycoside Trisaccharide Building Block and Its Use in the Assembly of Cryptococcus Neoformans Capsular Polysaccharide Fragments
por: Guazzelli, Lorenzo, et al.
Publicado: (2015)

Experimental modulation of capsule size in Cryptococcus neoformans
por: Zaragoza, Oscar, et al.
Publicado: (2004)

Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections
por: Dadachova, Ekaterina, et al.
Publicado: (2011)

Neutron Scattering Analysis of Cryptococcus neoformans Polysaccharide Reveals Solution Rigidity and Repeating Fractal-like Structural Patterns
por: Wang, Ziwei, et al.
Publicado: (2023)

Cryptococcus neoformans: Tripping on Acid in the Phagolysosome
por: DeLeon-Rodriguez, Carlos M., et al.
Publicado: (2016)

Mechanisms of Cryptococcus neoformans-Mediated Host Damage
por: Casadevall, Arturo, et al.
Publicado: (2018)

A detailed picture of a protein–carbohydrate hydrogen-bonding network revealed by NMR and MD simulations
por: Nestor, Gustav, et al.
Publicado: (2020)

The Buoyancy of Cryptococcus neoformans Is Affected by Capsule Size
por: Vij, Raghav, et al.
Publicado: (2018)

Melanization in Cryptococcus neoformans Requires Complex Regulation
por: Cordero, Radames J. B., et al.
Publicado: (2020)

Conformational Ensembles by NMR and MD Simulations in Model Heptapeptides with Select Tri-Peptide Motifs
por: Krishnan, V. V., et al.
Publicado: (2021)

The Incorporation of Labile Protons into Multidimensional NMR Analyses: Glycan Structures Revisited
por: Novakovic, Mihajlo, et al.
Publicado: (2021)

Last but not yeast—The many forms of Cryptococcus neoformans
por: Stempinski, Piotr R., et al.
Publicado: (2023)

Melaninization Reduces Cryptococcus neoformans Susceptibility to Mechanical Stress
por: Mattoon, Ellie Rose, et al.
Publicado: (2023)

Chemical structure and genetic organization of the E. coli O6:K15 capsular polysaccharide
por: Azurmendi, Hugo F., et al.
Publicado: (2020)

The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes
por: Alvarez, Mauricio, et al.
Publicado: (2009)

Melanin protects Cryptococcus neoformans from spaceflight effects
por: Cordero, Radames J. B., et al.
Publicado: (2022)

Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages
por: Alvarez, Mauricio, et al.
Publicado: (2007)

Pigment Production on L-Tryptophan Medium by Cryptococcus gattii and Cryptococcus neoformans
por: Chaskes, Stuart, et al.
Publicado: (2014)

Continental Drift and Speciation of the Cryptococcus neoformans and Cryptococcus gattii Species Complexes
por: Casadevall, Arturo, et al.
Publicado: (2017)

Cryptococcus neoformans melanization incorporates multiple catecholamines to produce polytypic melanin
por: Baker, Rosanna P., et al.
Publicado: (2021)

The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations
por: Martínez, J. Daniel, et al.
Publicado: (2020)

Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans
por: Decote-Ricardo, Debora, et al.
Publicado: (2019)

Epitope Location in the Cryptococcus neoformans Capsule Is a Determinant of Antibody Efficacy
por: Nussbaum, Gabriel, et al.
Publicado: (1997)

Role of Cln1 during melanization of Cryptococcus neoformans
por: García-Rodas, Rocío, et al.
Publicado: (2015)

Similar evolutionary trajectories in an environmental Cryptococcus neoformans isolate after human and murine infection
por: Sephton-Clark, Poppy, et al.
Publicado: (2023)

Intranasal Inoculation of Cryptococcus neoformans in Mice Produces Nasal Infection with Rapid Brain Dissemination
por: Coelho, Carolina, et al.
Publicado: (2019)

Phospholipids Trigger Cryptococcus neoformans Capsular Enlargement during Interactions with Amoebae and Macrophages
por: Chrisman, Cara J., et al.
Publicado: (2011)

Immune-Mediated Damage Completes the Parabola: Cryptococcus neoformans Pathogenesis Can Reflect the Outcome of a Weak or Strong Immune Response
por: Pirofski, Liise-anne, et al.
Publicado: (2017)

The Role of Host Gender in the Pathogenesis of Cryptococcus neoformans Infections
por: McClelland, Erin E., et al.
Publicado: (2013)

Sensitivity enhancement of homonuclear multidimensional NMR correlations for labile sites in proteins, polysaccharides, and nucleic acids
por: Novakovic, Mihajlo, et al.
Publicado: (2020)

Capsule Growth in Cryptococcus neoformans Is Coordinated with Cell Cycle Progression
por: García-Rodas, Rocío, et al.
Publicado: (2014)

Cryptococcus neoformans Capsular Enlargement and Cellular Gigantism during Galleria mellonella Infection
por: García-Rodas, Rocío, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_lqqfm1c1hl04n840t1l7negu96