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Comparison of TP53 Mutations in Myelodysplasia and Acute Leukemia Suggests Divergent Roles in Initiation and Progression

TP53 mutation predicts adverse prognosis in many cancers, including myeloid neoplasms, but the mechanisms by which specific mutations impact disease biology, and whether they differ between disease categories, remain unknown. We analyzed TP53 mutations in four myeloid neoplasm subtypes (MDS, AML, AM...

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Detalles Bibliográficos
Autores principales:	Jambhekar, Ashwini, Ackerman, Emily E., Alpay, Berk A., Lahav, Galit, Lovitch, Scott B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508817/ https://www.ncbi.nlm.nih.gov/pubmed/37732185 http://dx.doi.org/10.1101/2023.09.04.23295042

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