Exploring kinase DFG loop conformational stability with AlphaFold2-RAVE

Kinases compose one of the largest fractions of the human proteome, and their misfunction is implicated in many diseases, in particular cancers. The ubiquitousness and structural similarities of kinases makes specific and effective drug design difficult. In particular, conformational variability due...

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Detalles Bibliográficos
Autores principales: Vani, Bodhi P., Aranganathan, Akashnathan, Tiwary, Pratyush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cornell University 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10508826/
https://www.ncbi.nlm.nih.gov/pubmed/37731662

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