Biomarkers in osteoarthritis: current status and outlook — the FNIH Biomarkers Consortium PROGRESS OA study

Currently, no disease-modifying therapies are approved for osteoarthritis (OA) use. One obstacle to trial success in this field has been our existing endpoints’ limited validity and responsiveness. To overcome this impasse, the Foundation for the NIH OA Biomarkers Consortium is focused on investigat...

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Autores principales: Hunter, David J., Collins, Jamie E., Deveza, Leticia, Hoffmann, Steven C., Kraus, Virginia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509067/
https://www.ncbi.nlm.nih.gov/pubmed/36692532
http://dx.doi.org/10.1007/s00256-023-04284-w
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author Hunter, David J.
Collins, Jamie E.
Deveza, Leticia
Hoffmann, Steven C.
Kraus, Virginia B.
author_facet Hunter, David J.
Collins, Jamie E.
Deveza, Leticia
Hoffmann, Steven C.
Kraus, Virginia B.
author_sort Hunter, David J.
collection PubMed
description Currently, no disease-modifying therapies are approved for osteoarthritis (OA) use. One obstacle to trial success in this field has been our existing endpoints’ limited validity and responsiveness. To overcome this impasse, the Foundation for the NIH OA Biomarkers Consortium is focused on investigating biomarkers for a prognostic context of use for subsequent qualification through regulatory agencies. This narrative review describes this activity and the work underway, focusing on the PROGRESS OA study.
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spelling pubmed-105090672023-09-21 Biomarkers in osteoarthritis: current status and outlook — the FNIH Biomarkers Consortium PROGRESS OA study Hunter, David J. Collins, Jamie E. Deveza, Leticia Hoffmann, Steven C. Kraus, Virginia B. Skeletal Radiol Review Article Currently, no disease-modifying therapies are approved for osteoarthritis (OA) use. One obstacle to trial success in this field has been our existing endpoints’ limited validity and responsiveness. To overcome this impasse, the Foundation for the NIH OA Biomarkers Consortium is focused on investigating biomarkers for a prognostic context of use for subsequent qualification through regulatory agencies. This narrative review describes this activity and the work underway, focusing on the PROGRESS OA study. Springer Berlin Heidelberg 2023-01-24 2023 /pmc/articles/PMC10509067/ /pubmed/36692532 http://dx.doi.org/10.1007/s00256-023-04284-w Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Hunter, David J.
Collins, Jamie E.
Deveza, Leticia
Hoffmann, Steven C.
Kraus, Virginia B.
Biomarkers in osteoarthritis: current status and outlook — the FNIH Biomarkers Consortium PROGRESS OA study
title Biomarkers in osteoarthritis: current status and outlook — the FNIH Biomarkers Consortium PROGRESS OA study
title_full Biomarkers in osteoarthritis: current status and outlook — the FNIH Biomarkers Consortium PROGRESS OA study
title_fullStr Biomarkers in osteoarthritis: current status and outlook — the FNIH Biomarkers Consortium PROGRESS OA study
title_full_unstemmed Biomarkers in osteoarthritis: current status and outlook — the FNIH Biomarkers Consortium PROGRESS OA study
title_short Biomarkers in osteoarthritis: current status and outlook — the FNIH Biomarkers Consortium PROGRESS OA study
title_sort biomarkers in osteoarthritis: current status and outlook — the fnih biomarkers consortium progress oa study
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509067/
https://www.ncbi.nlm.nih.gov/pubmed/36692532
http://dx.doi.org/10.1007/s00256-023-04284-w
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