Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly

Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon – clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly people a...

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Autores principales: Belotserkovskaya, Ekaterina, Golotin, Vasily, Uyanik, Burhan, Demidov, Oleg N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509183/
https://www.ncbi.nlm.nih.gov/pubmed/37726289
http://dx.doi.org/10.1038/s41420-023-01590-z
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author Belotserkovskaya, Ekaterina
Golotin, Vasily
Uyanik, Burhan
Demidov, Oleg N.
author_facet Belotserkovskaya, Ekaterina
Golotin, Vasily
Uyanik, Burhan
Demidov, Oleg N.
author_sort Belotserkovskaya, Ekaterina
collection PubMed
description Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon – clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly people a minor clonal population of cells with mutations in certain genes, but without any sign of disease related to the hematopoietic system. Here we will review this recent advancement in the field of clonal haematopoiesis and how it may affect the disease’s development in old age.
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spelling pubmed-105091832023-09-21 Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly Belotserkovskaya, Ekaterina Golotin, Vasily Uyanik, Burhan Demidov, Oleg N. Cell Death Discov Review Article Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon – clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly people a minor clonal population of cells with mutations in certain genes, but without any sign of disease related to the hematopoietic system. Here we will review this recent advancement in the field of clonal haematopoiesis and how it may affect the disease’s development in old age. Nature Publishing Group UK 2023-09-19 /pmc/articles/PMC10509183/ /pubmed/37726289 http://dx.doi.org/10.1038/s41420-023-01590-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Belotserkovskaya, Ekaterina
Golotin, Vasily
Uyanik, Burhan
Demidov, Oleg N.
Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly
title Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly
title_full Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly
title_fullStr Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly
title_full_unstemmed Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly
title_short Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly
title_sort clonal haematopoiesis - a novel entity that modifies pathological processes in elderly
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509183/
https://www.ncbi.nlm.nih.gov/pubmed/37726289
http://dx.doi.org/10.1038/s41420-023-01590-z
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