Slow wave activity across sleep-night could predict levodopa-induced dyskinesia

A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID’s ap...

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Autores principales: Amato, Ninfa, Caverzasio, Serena, Manconi, Mauro, Staedler, Claudio, Kaelin-Lang, Alain, Galati, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509191/
https://www.ncbi.nlm.nih.gov/pubmed/37726375
http://dx.doi.org/10.1038/s41598-023-42604-1
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author Amato, Ninfa
Caverzasio, Serena
Manconi, Mauro
Staedler, Claudio
Kaelin-Lang, Alain
Galati, Salvatore
author_facet Amato, Ninfa
Caverzasio, Serena
Manconi, Mauro
Staedler, Claudio
Kaelin-Lang, Alain
Galati, Salvatore
author_sort Amato, Ninfa
collection PubMed
description A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID’s appearance, were included. Slow wave sleep epochs were extracted, combined and segmented into early and late sleep. SWA power was calculated. A linear regression model established that the SWA overnight decrease could predict the time to the emergence of LID. Our finding supports the link between SWA-mediated synaptic downscaling and the development of LID. If confirmed, it could pave the way to the study of possible sleep targeted therapies able to protect PD patients from LID development.
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spelling pubmed-105091912023-09-21 Slow wave activity across sleep-night could predict levodopa-induced dyskinesia Amato, Ninfa Caverzasio, Serena Manconi, Mauro Staedler, Claudio Kaelin-Lang, Alain Galati, Salvatore Sci Rep Article A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID’s appearance, were included. Slow wave sleep epochs were extracted, combined and segmented into early and late sleep. SWA power was calculated. A linear regression model established that the SWA overnight decrease could predict the time to the emergence of LID. Our finding supports the link between SWA-mediated synaptic downscaling and the development of LID. If confirmed, it could pave the way to the study of possible sleep targeted therapies able to protect PD patients from LID development. Nature Publishing Group UK 2023-09-19 /pmc/articles/PMC10509191/ /pubmed/37726375 http://dx.doi.org/10.1038/s41598-023-42604-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Amato, Ninfa
Caverzasio, Serena
Manconi, Mauro
Staedler, Claudio
Kaelin-Lang, Alain
Galati, Salvatore
Slow wave activity across sleep-night could predict levodopa-induced dyskinesia
title Slow wave activity across sleep-night could predict levodopa-induced dyskinesia
title_full Slow wave activity across sleep-night could predict levodopa-induced dyskinesia
title_fullStr Slow wave activity across sleep-night could predict levodopa-induced dyskinesia
title_full_unstemmed Slow wave activity across sleep-night could predict levodopa-induced dyskinesia
title_short Slow wave activity across sleep-night could predict levodopa-induced dyskinesia
title_sort slow wave activity across sleep-night could predict levodopa-induced dyskinesia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509191/
https://www.ncbi.nlm.nih.gov/pubmed/37726375
http://dx.doi.org/10.1038/s41598-023-42604-1
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