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Cross-species analysis of SHH medulloblastoma models reveals significant inhibitory effects of trametinib on tumor progression

Sonic Hedgehog (SHH) medulloblastomas (MBs) exhibit an intermediate prognosis and extensive intertumoral heterogeneity. While SHH pathway antagonists are effective in post-pubertal patients, younger patients exhibit significant side effects, and tumors that harbor mutations in downstream SHH pathway...

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Detalles Bibliográficos
Autores principales:	Borlase, Stephanie, DeCarlo, Alexandria, Coudière-Morrison, Ludivine, Liang, Lisa, Porter, Christopher J., Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509237/ https://www.ncbi.nlm.nih.gov/pubmed/37726268 http://dx.doi.org/10.1038/s41420-023-01646-0

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