Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents

Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked to Parkinson’s disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post-mortem brain of PD patients. Altered plasma and CSF PSAP levels correlate with PD-related motor impairments. Dopaminergic...

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Detalles Bibliográficos
Autores principales: He, Yachao, Kaya, Ibrahim, Shariatgorji, Reza, Lundkvist, Johan, Wahlberg, Lars U., Nilsson, Anna, Mamula, Dejan, Kehr, Jan, Zareba-Paslawska, Justyna, Biverstål, Henrik, Chergui, Karima, Zhang, Xiaoqun, Andren, Per E., Svenningsson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509278/
https://www.ncbi.nlm.nih.gov/pubmed/37726325
http://dx.doi.org/10.1038/s41467-023-41539-5

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