Repetitive DNA sequence detection and its role in the human genome

Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and regulating gene expression. In this review, we summarized the definition, arrangement, and structural characteristics of repeats. Besides, we introduced diverse biological functions of repeats and reviewed...

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Autores principales: Liao, Xingyu, Zhu, Wufei, Zhou, Juexiao, Li, Haoyang, Xu, Xiaopeng, Zhang, Bin, Gao, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509279/
https://www.ncbi.nlm.nih.gov/pubmed/37726397
http://dx.doi.org/10.1038/s42003-023-05322-y
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author Liao, Xingyu
Zhu, Wufei
Zhou, Juexiao
Li, Haoyang
Xu, Xiaopeng
Zhang, Bin
Gao, Xin
author_facet Liao, Xingyu
Zhu, Wufei
Zhou, Juexiao
Li, Haoyang
Xu, Xiaopeng
Zhang, Bin
Gao, Xin
author_sort Liao, Xingyu
collection PubMed
description Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and regulating gene expression. In this review, we summarized the definition, arrangement, and structural characteristics of repeats. Besides, we introduced diverse biological functions of repeats and reviewed existing methods for automatic repeat detection, classification, and masking. Finally, we analyzed the type, structure, and regulation of repeats in the human genome and their role in the induction of complex diseases. We believe that this review will facilitate a comprehensive understanding of repeats and provide guidance for repeat annotation and in-depth exploration of its association with human diseases.
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spelling pubmed-105092792023-09-21 Repetitive DNA sequence detection and its role in the human genome Liao, Xingyu Zhu, Wufei Zhou, Juexiao Li, Haoyang Xu, Xiaopeng Zhang, Bin Gao, Xin Commun Biol Review Article Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and regulating gene expression. In this review, we summarized the definition, arrangement, and structural characteristics of repeats. Besides, we introduced diverse biological functions of repeats and reviewed existing methods for automatic repeat detection, classification, and masking. Finally, we analyzed the type, structure, and regulation of repeats in the human genome and their role in the induction of complex diseases. We believe that this review will facilitate a comprehensive understanding of repeats and provide guidance for repeat annotation and in-depth exploration of its association with human diseases. Nature Publishing Group UK 2023-09-19 /pmc/articles/PMC10509279/ /pubmed/37726397 http://dx.doi.org/10.1038/s42003-023-05322-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Liao, Xingyu
Zhu, Wufei
Zhou, Juexiao
Li, Haoyang
Xu, Xiaopeng
Zhang, Bin
Gao, Xin
Repetitive DNA sequence detection and its role in the human genome
title Repetitive DNA sequence detection and its role in the human genome
title_full Repetitive DNA sequence detection and its role in the human genome
title_fullStr Repetitive DNA sequence detection and its role in the human genome
title_full_unstemmed Repetitive DNA sequence detection and its role in the human genome
title_short Repetitive DNA sequence detection and its role in the human genome
title_sort repetitive dna sequence detection and its role in the human genome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509279/
https://www.ncbi.nlm.nih.gov/pubmed/37726397
http://dx.doi.org/10.1038/s42003-023-05322-y
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