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Dynamic association of the intramembrane proteases SPPL2a/b and their substrates with tetraspanin-enriched microdomains

Signal peptide peptidase-like 2a and b (SPPL2a/b) are aspartyl intramembrane proteases and cleave tail-anchored proteins as well as N-terminal fragments (NTFs) derived from type II-oriented transmembrane proteins. How these proteases recruit substrates and cleavage is regulated, is still incompletel...

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Detalles Bibliográficos
Autores principales:	Leinung, Nadja, Mentrup, Torben, Patel, Mehul, Gallagher, Tom, Schröder, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509304/ https://www.ncbi.nlm.nih.gov/pubmed/37736044 http://dx.doi.org/10.1016/j.isci.2023.107819

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